Zofran - the description, contraindications, application

The latin name: Zofran

Zofran Pharmacological groups: Antiemetics agents

Zofran Working substance: (Ondansetron *)

Zofran Application: the Nausea and a vomiting (prophylaxis) at a cytotoxic chemotherapy (initial and repeated courses, including use of high doses of Cisplatinum), radial therapy (an irradiation of all surface of a body, partial unitary or a daily irradiation of transabdominal area), in the postoperative period.

Zofran Contraindications: Hypersensitivity, failure of function of a liver, surgical operations on a belly cavity, pregnancy (especially the first 3 ), a feeding a breast (for the period of treatment stop), children's age: till 2 years in case of an anaesthesia, till 4 years - at a chemotherapy, all age group - at radial therapy and for purpose .

Zofran Side effects: the Constipation, a diarrhea, dryness in a mouth, a hiccup, transitional rising of nuclear heating plant and , hepatic failure (the lethal outcome is possible, it is especial on a background hepatotoxic therapies and antibiotics), a headache, a giddiness, infringements of vision (an illegibility, frustration of an accommodation), a caumesthesia and a rush of blood to the person, oppression, delicacy, convulsive attacks, an extrapyramidal symptomatology, a hypokalemia, a tachycardia or a bradycardia, a hypotension, syncopes, stethalgias (anginous type), infringements , including blockade of II degree, a fever, allergic reactions: a urticaria, a bronchospasm, a Quincke's disease, an anaphylaxis, a pain, a reddening and a burning sensation in a place of an injection; a burning sensation in the field of a fundament and a rectum.

Zofran Way of application and dose: inside of (tablets, a syrup). The adult at moderate chemotherapies and radial therapy originally: 8 mg, unitary slowly directly ahead of the beginning of a course or inside for 0,5-1-2 prior to the beginning and once again through 8-12 ; 16 mg for 1-2 prior to the beginning of therapy; to adults and teenagers of 12 years also is more senior it is possible to enter during 15 mines - 32 mg unitary for 30 mines prior to the beginning of a course or on 0,15 mg / kg 3 times - for 30 mines prior to the beginning of a chemotherapy and then through 4 and 8 . For prophylaxis of a late nausea and a vomiting (including through 24 ): on 8 mg inside everyone 12 or 16 mg 1 time day, 1-2 days (if necessary 3-5 days) after the termination of a course of a chemotherapy; in case of radial therapy - on 8 mg inside for 1-2 before procedure, at an irradiation of all body - daily, at partial an irradiation of a stomach - everyone 8 during a course. The adult at chemotherapies - are possible 3 variants initial :I - unitary, 8 mg slowly directly ahead of the beginning of a course; II - in the beginning 8 mg slowly directly ahead of therapy, then on 8 mg slowly 2 more times with an interval 2-4 or on 1 mg / during 24 ; III - unitary 32 mg, divorced in 50-100 ml of a normal saline solution, during not less than 15 mines, directly ahead of the beginning of a course. For prophylaxis of a vomiting the next days - 8 mg inside of 2 times day within 5 days or after the termination of a course of a chemotherapy. At children from 4 till 12 years at chemotherapies are possible 2 regimens initial :I - unitary 5 mg / m2 directly ahead of the beginning of a course, then 4 more mg inside through 12 , II - on 4 mg inside of 3 times, for 30 mines prior to the beginning of a course, then through 4 and 8 . For prophylaxis of the deferred vomiting - on 4 mg inside everyone 8 1-2 days or 2 times in day within 5 days after the termination of a course of a chemotherapy. C the purpose of prevention of a postoperative nausea and a vomiting: adult - 16 mg inside for 1 up to an anaesthesia or 4 mg , directly ahead of an introduction narcosis (not less, than for 20 with, it it is preferable for 2-5 mines), or slowly or during an introduction narcosis; to children - 0,1 mg / kg (about 4 mg), slowly up to (are maximum not less, than for 30 ), during time and after an introduction narcosis. For a cupping of a developed postoperative nausea and a vomiting: adult - 4 mg or , to children - 0,1 mg / kg (up to 4 mg) slowly. At the expressed infringements of a liver - the maximal daily dose - 8 mg (general at intake or unitary at introduction during 15 mines).

Zofran Special indicatings: it is not recommended to enter in one syringe with other preparations. forms plant only advisable solutions. We compose with solutions of a sodium and a potassium of Sodium chloridum, a glucose, Mannitum, , Cisplatinum, Doxorubicinum, Dexamethazonum. Before their introduction it is necessary to be convinced of absence of large particles and discolorations (if the container allows); a precipitate contained on walls of an ampoule (activity and safety does not influence), dissolve by vigorous stirring; ampoules not , protect from influence of light.

Trading names of preparations with working substance (Ondansetron *):
(Atossa) (Ondansetron-LANS) (Emeset) (Vero-Ondansetron) a hydrochloride (Ondansetron hydrochloride) (Emetron) (Zofran) a hydrochloride (Ondansetronum hydrochloridum dihydrate) (Latranum) (Ondasol)