Xalatan - the description, contraindications, application

The latin name: Xalatan

Xalatan Pharmacological groups: Prostaglandinums, thromboxane, leukotriene and their antagonists

Xalatan Working substance: (Latanoprost *)

Xalatan Application: On data Physicians Desk Reference (2003), it is shown at the raised ophthalmotonus at patients with an open angle glaucoma and an eye hypertension, including at tolerance to others dropping to agents or their insufficient efficiency.

Xalatan Contraindications: Hypersensitivity.

Xalatan Restrictions to application: Pregnancy, thoracal feeding, children's age (safety and efficiency of application are not fixed); active inflammatory process in an eyeglobe (an iritis, a uveitis), an aphakia, a pseudo-aphakia with damage of a capsule of a lens, the conditions accompanying with risk of development of a macular edema, a glaucoma with the phenomena of an inflammation or , carrying of contact lenses, defeats of a liver and kidneys.

Xalatan Application at pregnancy and a feeding a breast At pregnancy and a feeding a breast it is necessary to apply with care, only if the expected advantage for mother exceeds potential risk for a fetus and the child.

Xalatan Side effects: Change of eyelashes (augmentation of length, thickness, a pigmentation and number of eyelashes), dimness of a skin of blepharons, an inflammation (an iritis, a uveitis), change of a pigmentation of an iris, a macular edema. On the data , double blind, controllable tests, at 5-15 % of the patients receiving during 6 , the following collateral reactions were marked on the part of eyes: visions, sensation of a pricking and a burning sensation, a hyperemia of a conjunctiva (less than at 1 % of patients the termination of treatment was required in connection with an intolerance of a conjunctival hyperemia), sensation of a foreign body in an eye, an itch, intensifying of a pigmentation of an iris, dot epithelial . At 1-4 % of patients crusts a few blepharons ago, pain / discomfort in blepharons, an edema and a hyperemia of blepharons, a photophobia were marked a xeroma, superfluous , a pain in an eye. Less than at 1 % of patients have been marked a conjunctivitis, , allocation from an eye. Vitreous hemorrhages were extremely seldom marked an embolism of arterias of a retina, retinas, at a diabetic retinopathy. Most frequently meeting systemic by-effects: at 4 % of patients infections of the top respiratory ways , at 1-2 % - a stethalgia a/stenocardia, a pain in muscles / , eruption / allergic dermal reactions were marked. In postmarketing observations have been marked: a bronchial asthma or an exacerbation of a bronchial asthma, an edema and anabroses of a cornea, , changes of eyelashes and hair (augmentation of length, thickness, a pigmentation and number), dimness of a skin of blepharons, a keratitis, an inflammation (an iritis, a uveitis), a keratitis, a macular edema, infringement of a direction of body height of the eyelashes, adducting in a boring of an eye, a toxic epidermal necrolysis. As reports on these by-effects acted from a population of unknown volume voluntary, i.e. Were not supervised properly and, probably, have been connected not only to application , but also with other factors, it is impossible to estimate their importance and frequency.

Xalatan Interaction: it is incompatible with (the precipitation is possible, and between applications it is necessary not less than a 5-minute interval). It can simultaneously be applied with other agents dropping (and in this case it is necessary not less than a 5-minute interval).

Xalatan Overdosage: Signs: a boring of eyes, conjunctival or a hyperemia. /introduction of high doses to monkeys caused transient , but his use at 11 patients with a bronchial asthma did not induce a bronchospasm. /introduction to healthy volunteers in a dose up to 3 mkg / kg, providing excess of his average plasma concentration in comparison with use of medical doses in 200 times, did not cause collateral reactions. /introduction of 5,5-10 mkg / kg caused an abdominal pain, a giddiness, fatigability, inflow of fever, a nausea, a sweating. Treatment: symptomatic.

Xalatan Way of application and dose: on 1 drop (1,5 mkg) in the struck eye, 1 time in day in the evening.

Xalatan Safety measures: it is not necessary to apply more often than 1 time day since more often introduction can decrease medical effect. It is necessary to warn the patient about necessity of urgent consultation of the doctor at development of any undesirable reactions on the part of eyes (a conjunctivitis, change of blepharons, etc.). Development of a bacterial keratitis is connected to use bottles of ophthalmologic agents (since contents of an open bottle does not keep a sterility), and also with presence of in most cases combined pathology of an eye and damages of an epithelium of an eyeglobe. At development of intercurrent illnesses of an eye (a trauma, an infection, etc.) Or a surgical intervention on an eyeglobe it is necessary to consult immediately with the doctor about use of ophthalmologic agents in bottles (it is possible contents of a bottle pathogenic flora). Prior to the beginning of therapy of the patient it is necessary to inform on a possible irreversible discoloration of eyes (especially at treatment only one eye when the irreversible heterochromia can develop), change of length, thickness, color and number of eyelashes and hair, directions of body height of eyelashes and dimness of a skin of blepharons. Regular ophthalmologic inspection is necessary; at intensifying a pigmentation treatment can be stopped. Before it is necessary to remove contact lenses (Sodium chloridum contained in a solution can be adsorbed on lenses); they are put on later with 15 mines after . Application counterindicatives at patients with hypersensitivity to Sodium chloridum and to other auxiliary components of a preparation.

Trading names of preparations with working substance (Latanoprost *):
(Xalatan)