Viramune - the description, contraindications, application

The latin name: Viramune

Viramune Pharmacological groups: Antiviral agents

Viramune Application: Treatment and prophylaxis of the HIV - 1 of an infection. At purpose of a preparation as monotherapy to it quickly and practically virus fastness always develops, therefore it should be appointed always in a combination at least with two others preparations.

Viramune Contraindications: Hypersensitivity.

Viramune Application at pregnancy and a feeding a breast: Application at pregnancy is possible only in the event that the expected effect of therapy exceeds potential risk for a fetus. For the period of treatment it is necessary to stop thoracal feeding.

Viramune Side effects: Dermal reactions (including caused Stevens by set of symptoms - Johnson and a toxic epidermal necrolysis), change of parameters of a functional condition of a liver (rising of activity , nuclear heating plant, scale - , the general bilirubin and an alkaline phosphatase), an icterus, a hepatitis, a nausea, undue fatiguability, a fever, a headache, a sleepiness, a vomiting, a diarrhea, an abdominal pain, , a granulocytopenia (is more often at children), allergic and other reactions of hypersensitivity (an anaphylaxis, a Quincke's disease, a urticaria, a lymphadenopathy, an eosinophilia, etc.).

Viramune Interaction: Can decrease concentration in plasma of the preparations actively metabolized with the help of enzymes 450 (correction of a dose can be demanded). It is not required changes of a regimen of batching at use in a combination with analogues of nucleosides ; it is not fixed clinically significant interaction with inhibitors of proteases. Reduces the area under a curve concentration - time (AUC) and Cmax , and enlarges concentration in plasma by 15-28 % (it is not necessary to appoint simultaneously, it is possible to replace with preparations with renal way of deducing, for example ears - 4 mg / kg of 1 times day during 2 , then in a daily dose of 7 mg / kg in 2 receptions; from 8 years also is more senior - than 4 mg / kg of 1 times day during 2 , then in a dose of 4 mg in 2 receptions. The daily dose at patients of any age should not exceed 400 mg. Prophylaxis of transfer of a HIV from mother to the child: unitary mothers during labors of 200 mg, with the subsequent unitary peroral introduction newborn during 72 after a birth in a dose of 2 mg / kg.

Viramune Safety measures: Reception should be immediately stopped, if the patient has expressed rashes, including with attributes of a generalization of process, at the moderate or expressed changes of activity of a liver (before normalization), repeated change of its functional condition. Up to and during therapy it is necessary to supervise a condition of a liver and integuments (it is especial during the first 8 treatments). It is necessary to be careful at purpose to patients with renal and hepatic failure. Reception should be made daily, according to prescriptions, the dose should not change without consultation of the doctor. If the next dose has been missed, following (not doubling) accept as soon as possible. It is intended only for the combined therapy with agents (at monotherapy fastness of viruses quickly develops), preferably such which were not used by the patient earlier.

Viramune Special indicatings: At the patients receiving or others preparations, progressing diseases, including the opportunistic infections connected to the HIV - 1 by an infection is possible. In this connection patients should be under constant observation of the doctors who are possessing experience of treatment of diseases, connected with the HIV - 1 an infection. The remote effects of a preparation now are unknown. The risk of infection of other people of the HIV - 1 an infection at therapy by a preparation does not decrease. With infringement of function of the kidneys, taking place on a dialysis, additional reception of a preparation in a dose of 200 mg after each procedure of a dialysis is recommended to patients (correction of a dose is not required at Cl a creatinine? 20 ml / mines). At occurrence of a sleepiness it is recommended to refuse management of vehicles and machine equipment.