Vibramycin (Vibramycinum) - the description, contraindications, application

The latin name: Vibramycin

Vibramycin Pharmacological groups: Tetracyclinums

Vibramycin Working substance: (Doxycycline *)

Vibramycin Application: the Infections caused Haemophilus influenzae, endocellular pathogenic microorganisms (clamydia, mycoplasmas), rickettsial vasculitis, Borrelia (a preparation of a choice); infectious diseases: fever , a spotty fever of rocky mountains, typhoids, borreliosis, brucellosis, Yersinia, a bacillar and amebic dysentery, a tularemia, a cholera, illness Lima (I a stage), an actinomycosis, a malaria, a canicola fever, a trachoma, a psittacosis, granulocytic ehrlichin, etc.; diseases of BODIES and the bottom departments of respiratory ways (a sinusitis, an otitis, a tonsillitis, an acute bronchitis, exacerbations of a chronic bronchitis, a pneumonia, a pleuritis), a cholecystitis, a cholangitis, a peritonitis, a proctitis, a periodontitis, infections of urinary ways, a urogenital mycoplasmosis, inflammatory diseases of bodies of a small basin in an acute stage at women (endometritis), an acute prostatitis, an epididymitis, a gonorrhea, a lues, purulent infections of a skin and soft tissues, covered with blackheads an eruption, infectious ulcerative keratites. Prophylaxis surgical infections after medical abortions, operations on a colon, prophylaxis of the malaria caused Plasmodium falciparum, at short-term travel (less than 4 month) in territory where the resistance of a plasmodium to chloroquine and-or Pyrimethaminum - sulfadimidine is marked.

Vibramycin Contraindications: Hypersensitivity, a porphyria, serious hepatic failure, a leukopenia, pregnancy (second half), a feeding a breast (for the period of treatment it is necessary to refrain from thoracal feeding), age till 9 years (the period of development of a teeth).

Vibramycin Side effects: the Giddiness, a sweating, a vascular collapse, a good-quality intracranial hypertension at adults and a diverticulum of fontanels at children, a nausea, a vomiting, an anorexia, , a diarrhea, a constipation, a dysphagia, a glossitis, an esophagitis, a dysbacteriosis, fungoid infections, reinfections resistant , an eosinophilia, a neutropenia, a photosensitization, a steady discoloration of an adamantine substance of tooth, allergic reactions (an eruption, a dermal itch, a Quincke's edema).

Vibramycin Interaction: the Adsorption reduces simultaneous reception of iron preparations, Sodium hydrogenum, aluminium, calcium or magnesian antacid, purgative. Karbamazepinum, Phenytoinum, Rifampicinum reduce concentration in plasma and reduce T1/2 (an induction of monooxygenases and acceleration of a biotransformation), that can result in downstroke of antimicrobial effect. Reduces bactericidal action of Penicillinums. The regular use of alcohol enlarges T1/2. Reduces reliability of contraception and raises frequency bleedings on a background peroral contraceptives. effect of indirect anticoagulants.

Vibramycin Way of application and dose: Inside, after meal (it is possible to wash down with milk or kefir), / during 1-4 (originally contents of an ampoule (0,1 ) dissolve in 10 ml of water for injections, then dilute the received solution in 1000 ml of a normal saline solution). An initial daily dose for adults 0,1-0,2 (it is possible in two steps), in the further 0,1. To children of 9-12 years - 4 mg / kg day in the first day and 2 mg / kg - further. At inflammatory diseases of a small basin at women in an acute stage - / 0,1 everyone 12 , it is usual in a combination with cephalosporins III generations; purpose inside (after preliminary parenteral introduction clindamycin and gentamycin) 0,1 2 time / day within 14 days is possible. For prophylaxis of infections after medical abortion - 0,1 inside for 1 before abortion and 0,2 inside through 30 mines the ambassador. At an initial and secondary lues - 0,3 mg day not less than 10 days. At a gonorrhea 0,1 2 time / day within 2-4 days, or unitary 0,3. At eruptions 0,05 /, a course 6-12 .

Vibramycin Safety measures: Treatment of the infections caused -and staphylococcuses, is possible only after definition of sensitivity of microorganisms to a doxycycline. For prophylaxis of ulcerations of an esophagus it is necessary to accept with a plenty of a liquid. During treatment and within 4-5 days after him the direct insolation or by beams (photosensitization) counterindicatives. At long application it is necessary to supervise on a regular basis cellular structure of a peripheric blood, to carry out functional hepatic assays, to define nitrogen and a urea in Serum. Sodium sulfitums contained in a syrup can cause allergic reactions down to an anaphylaxis and serious attacks of a bronchial asthma. At use peroral contraceptives it is necessary to apply additional agents of contraception or to change its method. Probably false rising of a level of catecholamins in urine at their definition by a fluorescent method. At research biopsy material a thyroid gland at patients, it is long receiving a doxycycline, it is necessary to take into account an opportunity dark brown paint over tissues in micropreparations.

Trading names of preparations with working substance (Doxycycline *):
Vibramycinum (Vibramycin) the Doxycycline - (Doxycyclin-AKOS) the Doxycycline a hydrochloride in capsules (Doxycyclini hydrochloridum in capsules) (Doxal) the Doxycycline - (Doxycyclin-Ferein) Medomycinum (Medomycin) (Doxydar 100) the Doxycycline a hydrochloride (Doxycycline hydrochloride) (Unidox Solutab) the Doxycycline (Doxycyclin) the Doxycycline a hydrochloride 0,1 (Doxycyclini hydrochloridum 0,1 g) Doxycycline (Doxycycline Stada) the Doxycycline a hydrochloride 0,1 in capsules (Doxycyclini hydrochloridum 0,1 g in capsules)