Buy Topamax online:
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Topamax - the description, contraindications, application
The latin name: Topamax
Topamax Pharmacological groups: Antiepileptic agents
Topamax Working substance: Topiramate
Topamax Application: Partial or generalized -clonic attacks as monotherapy and in a combination with other anticonvulsants; padding therapy at treatment of the attacks connected to set of symptoms - (at adults and children); for the first time the diagnosed epilepsy (at adults and children than 2 years are more senior).
Topamax Contraindications: Hypersensitivity.
Topamax Restrictions to application: Pregnancy, a feeding a breast, children's age (safety and efficiency of application for children till 2 years are not determined).
Topamax Application at pregnancy and a feeding a breast: it is Possible, if the expected effect of therapy exceeds potential risk for a fetus (adequate and controllable researches on application during pregnancy it was not carried out). For the period of treatment it is necessary to stop thoracal feeding.
Topamax Side effects: From the side of nervous system and sense organs: undue fatiguability, an ataxia, infringement of thinking and concentration of attention, an emotional lability, a confusion of consciousness, a giddiness, a paresthesia, a hypesthesia, a sleepiness; rarely - exaltation, an amnesia, an aphasia, depression, a diplopia and other infringements of vision, a conjunctivitis, a nystagmus, infringement of speech, a distortion of gustatory sensations. From the side of bodies of the GASTROINTESTINAL TRACT: an anorexia, a ulitis, a nausea. Other: decrease of mass of a body, an abdominal pain, a fever, a leukopenia, a dyspnea, an edema, a nasal bleeding, a nephrolithiasis, a hematuria, , , a dysmenorrhea, weakening of a libido, an impotency.
Topamax Interaction: Phenytoinum and Karbamazepinum depress the maintenance in a blood. reduces AUC digoxin (by 12 %), a level of Phenytoinum in plasma and efficiency of peroral contraceptives. Simultaneous application with the drugs contributing to a nephrolithiasis, can enlarge risk of formation of stones in kidneys.
Topamax Overdosage: Signs: intensifying of side effects. Treatment: a gastric lavage or an induction of a vomiting, a maintenance therapy. In serious cases probably carrying out of a haemodialysis.
Topamax Way of application and dose: Inside (irrespective of reception of nutrition). The adult at monotherapy: an initial dose - 25 mg of 1 times day (for the night) during 1 weeks, then a dose enlarge on 25-50 a milligram/day (divide into 2 receptions) with an interval 1-2 weeks up to achievement of clinical effect; an advisable dose - 100 milligram/day, maximal diurnal - 500 mg (for some patients with refractory forms of an epilepsy - up to 1000 milligram/day). To children than 2 years are more senior: in the first week of treatment - 0,5-1 mg / kg for the night, then a dose enlarge by 0,5-1 mg (divide into 2 receptions) with an interval 1-2 weeks; advisable doses - 3-6 mg (for children with recently diagnosed partial attacks - up to 500 milligram/day). In a combination to other antispasmodic drugs: adult - 25-50 mg for the night during 1 weeks, then a dose enlarge by 25-50 mg with an interval 1-2 weeks and accept in 2 receptions; a minimum efficient dose - 200 milligram/day, center diurnal - 200-400 mg, maximal - 1600 mg. To children than 2 years are more senior: - 1-3 mg for the night during 1 weeks, then a dose enlarge by 1-3 mg / kg with an interval 1-2 weeks and accept in 2 receptions; an advisable daily dose - 5-9 mg / kg.
Topamax Precautionary measures: the Patients who are taking place on a haemodialysis, in days of his carrying out it is necessary to yield a padding dose (approximately 1/2 day time doses) before procedure. A cancellation carry out gradually, reducing a dose on 100 mg with week intervals. At patients with the raised risk of a nephrolithiasis adequate rising volume of a consumed liquid is recommended. With care apply at patients with infringement of function of a liver (because of possible downstroke of a clearance ). Cases of occurrence of the secondary angle-closure glaucoma at children and adults are possible. In case of appreciable loss of mass of a body at treatment the suralimentation or application of alimentary additives is necessary. It is not necessary to apply in an operating time to drivers of vehicles and people which trade is connected to the raised concentration of attention. It is not recommended to accept simultaneously with alcohol or the drugs oppressing with the CNS.
Trading names of drugs with working substance Topiramate:
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