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Tobrex - the description, contraindications, application
The latin name: Tobrex
Tobrex Pharmacological groups: Aminoglycosides
Tobrex Working substance: Tobramycin
Tobrex Application: Serious bacterial infections: a hematosepsis at newborns, children and adults, an infection of the bottom departments of a respiratory path, including at a mucoviscidosis, an empyema of a pleura, a meningitis; infections of a belly cavity, including a peritonitis, infections of a skin and the bones, the complicated and relapsing infections of a urinary path. Eye drops - external infections of an eye and his appendages.
Tobrex Contraindications: Hypersensitivity, including to other aminoglycosides, a myasthenia, a parkinsonism, chronic renal failure, infringements of function VIII steams of cranial nerves, a dehydration, pregnancy, advanced age.
Tobrex Side effects: the Irreversible damage of vestibular and acoustical branches VIII steams of craniocerebral nerves with partial or complete bilateral deafness, giddinesses, a vertigo, a sonitus, a headache, disorientations, a sleepiness, paresthesias, muscle fascicularities, cramps, infringement of function of kidneys (an oliguria, a cylindruria, a proteinuria, canalicular infringements, rising of a level of a creatinine and a urea nitrogen), an anemia, a leukopenia, a granulocytopenia, a thrombocytopenia, a leukocytosis, an eosinophilia, a nausea, a diarrhea, rising of activity of transaminases and the LACTATE DEHYDROGENASE, a level of a bilirubin, a hypocalcemia, a hyponatremia, a hypomagnesemia, a fever, an eruption, a dermal itch, an anaphylaxis. At conjunctival application - local allergic reactions as an itch, a swelling of blepharons.
Tobrex Interaction: Rises neuro and a nephrotoxicity of other drugs. The probability of by-effects is enlarged on a background of loopback diuretics (Furosemidum, an acid ethacrynic). The decamethonium, a tubocurarine, rise risk of development of a myoneural block.
Tobrex Overdosage: It Is displaid by infringements of function of kidneys, acute renal failure, acoustical and vestibular infringements, a myoneural block, a paralysis of a respiratory musculation. Treatment: maintenance of adequate ventilation and an oxygenation, a hydration (excretion of urine not less than 3-5 ml / ¬ú/þ) under the control of balance of a liquid, Cl a creatinine, a level of Tobramycinum in plasma; carrying out of a haemodialysis.
Tobrex Way of application and dose: Intramuscularly, intravenously, conjunctival. For adults a sating dose - 1,5-2,0 mg / kg, bolstering - from 3 mg in three steps (everyone 8 ) up to 5 mg in 6 h. To children - 6,0-7,5 mg in 3-4 receptions, premature and to newborns - up to 4 mg in two steps. Routine duration of a course - 7-10 days. For intravenously infusions plant in 50-100 ml of an isoosmotic solution of a sodium of Sodium chloridum or 5 % of a solution of a glucose, enter it is trickling within 20-60 minutes. Eye drops - conjunctival, on 1 drop in an eye, 5 times day, at acute infections are possible - through 30 mines - 1 h.
Tobrex Precautionary measures: Patients should be under the strict medical control over high potential risk of neurotoxic and nephrotoxic effects, it is recommended to carry out audiometrical tests on a regular basis. It is necessary to mean, that at lines of patients irreversible partial or complete deafness can already be generated after the termination of treatment. At augmentation of volume of distribution of a drug (pregnancy, combustions, a peritonitis, an infection of retroperitoneal space) for achievement of efficiency concentration the dose should be raised, and at critical states and at young patients with high cardiac exhaust and rate of a glomerular filtration - to increase frequency of introduction. With renal failure it is necessary for elderly patient and patient to lower a dose or to increase intervals between introductions. Regular definition of a level of a creatinine, a urea nitrogen, calcium, a sodium, magnesium in plasma is shown, to relative density of urine, protein in urine, a urinary deposit. Long local application can result in a superinfection, including fungic. Feeding mothers are recommended to suspend thoracal feeding.
Trading names of drugs with working substance Tobramycin:
Tobrex Brulamycinum (Brulamycin) Nebcinum (Nebcin) the Tobrex (Tobrex)
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