Ticlid - the description, contraindications, application

The latin name: Ticlid

Ticlid Pharmacological groups: Antiaggregants

Ticlid Working substance: Ticlopidine

Ticlid Application: Acute a myocardial infarction (early stages and the rehabilitational period), a unstable stenocardia, transient infringements of a cerebral circulation (the secondary prophylaxis of an insult), conditions after a prosthetic repair of valves of heart, an aortocoronary shunting (with the venous shunt) and angioplasties (a balloon dilatation), a serious atherosclerosis of the peripheric arterias, an alternating lameness, a chronic glomerulonephritis, a sickemia, a microangiopathy at a diabetes.

Ticlid Contraindications: Hypersensitivity, acute round ulcers of a stomach, danger of a bleeding at an exacerbation of a peptic ulcer of a stomach and a duodenal intestine, an intracraneal hemorrhage (including anamnestic indicatings), a hemorrhagic diathesis, a neutropenia, a thrombocytopenia, serious infringements of function of a liver, an acute hemorrhagic insult, pregnancy, a feeding a breast (refusal of thoracal feeding is obligatory).

Ticlid Restrictions to application: the Traumas, scheduled surgical operation (the cancellation for 2 weeks is necessary); children's age.

Ticlid Side effects: Gastrointestinal frustration (a diarrhea, a nausea, a vomiting, downstroke of appetite, an abdominal pain, a meteorism), less often - bleedings, hemorrhagic rashes, a hematuria, a thrombocytopenia, a neutropenia (in the first 3 month), a serious agranulocytosis, a pancytopenia, an aplastic anemia (single instances), a giddiness, a headache, a sonitus, an asthenia, augmentation of the maintenance of a cholesterin and triglycerides in Serum of a blood, rising of activity of transaminases and an alkaline phosphatase (in the first 1-4 month), a cholestatic icterus, an eruption, an itch.

Ticlid Interaction: Rises inhibiting influence of Acidum acetylsalicylicum and other NONSTEROIDAL ANTI-INFLAMMATORY DRUGSES on collagen-induced aggregation of thrombocytes and enlarges risk of bleedings (including on a background of Heparinum and indirect anticoagulants). Antacids, reducing an adsorption, reduce concentration in plasma on 18 %; Cimetidinum, blocking microsomal oxidation, reduces Cl on 50 %. By 15 % reduces a level of digoxin in bloods, a clearance of Theophyllinum. Fortifies Phenytoinum in plasma.

Ticlid Overdosage: the Hemorrhagic set of symptoms, cramps, a hypothermia, a short wind, vestibular infringements. At carrying out of postmarketing tests one case of an overdosage (38-years the man has taken over lumpsum 6 g without any serious complications - the augmentation of a bleeding time and a level of transaminases was marked) is described.

Ticlid Way of application and dose: Inside, during meal - on 250 mg 2 times day; at a good acceptability the dose can be enlarged up to 750 milligram/day. At renal failure downstroke of a dosage is shown.

Ticlid Precautionary measures: During treatment the control of cellular composition of a peripheric blood and a condition of coagulating system is desirable.

Trading names of drugs with working substance Ticlopidine:
(Tagren) the Ticlid (Ticlid) - (Ticlopidin-ratiopharm)