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Largactil ( Thorazine, Generic Chlorpromazine ) - Product Origin: New Zealand	LARGACTIL is indicated in the following conditions:1.Schizophrenia and other psychoses (especially paranoid), mania and hypomania. 2.In anxiety psychomotor agitation excitement, violent or dangerously impulsive behaviour. LARGACTIL is used as an adjunct in the short-term management of these conditions. 3.Intractable hiccup. 4.Nausea and vomiting of terminal illness (where other medicines have failed or are not available). 5.Induction of hypothermia is facilitated by LARGACTIL which prevents shivering and causes vasodilation. 6.Childhood schizophrenia and autism. Dosage and AdministrationOral administration should be used whenever possible. Dosages should be low to begin with and gradually increase under close supervision until the optimum dosage within the recommended range for the individual is reached. Individuals vary considerably and the optimum dose may be affected by the formulation used.The parenteral formulation may be used in emergencies. It may only be administered by deep intramuscular injection. LARGACTIL is too irritant to give subcutaneously. Repeated injections should be avoided if possible.Schizophrenia, Psychoses, Anxiety and AgitationOralAdultInitially 25 mg three times daily or 75 mg at bedtime increasing by daily amounts of 25 mg to an effective maintenance dose. This is usually in the range 75 to 300 mg daily, but some patients may require up to 1 g daily.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years: 0.5 mg/kg bodyweight every 4 - 6 hours to a maximum recommended dose of 40 mg daily.6 -12 Years: A third to half the adult dose, to a maximum recommended dose of 75 mg daily.ElderlyStart with a third to a half the usual adult dose with a more gradual increase in dosage.IntramuscularAdultFor acute relief of symptoms 25 - 50 mg every 6 - 8hours.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Dosage is not advised to exceed 40 mg daily.6-12 Years: 0.5 mg/kg bodyweight every 6 - 8 hours. Not to exceed 75 mg daily.ElderlyDoses in the lower range for adults should be sufficient to control symptoms, i.e. 25 mg, 8 hourly.Intractable HiccupOralAdult25 - 50 mg three or four times daily.ChildrenNo information available.ElderlyNo information available.IntramuscularAdult25 - 50 mg every 6-8 hours. .ChildrenNo information available.ElderlyNo information availableIntravenous InfusionAdultIf other routes of administration are inappropriate, give 25-50 mg in 500-1000 ml sodium chloride by slow intravenous infusion every 6-8 hours.ChildrenNo information available.ElderlyNo information available.Induction of hypothermia to prevent shiveringIntramuscularAdult25 - 50 mg every 6 - 8 hours.ChildrenUnder 1 Year: Do not use in children this age.1-12 Years: Initial dose: 0.5 - 1.0 mg/kg. Maintenance: 0.5 mg/kg every 4 - 6 hours.ElderlyNo information available.Nausea and Vomiting of Terminal IllnessOralAdults10 - 25 mg every 4 - 6 hours.ChildrenUnder 1 Year: Do not use unless need is life saving.1-5 Years; 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 40 mg.6 - 12 Years: 0.5 mg/kg every 4 - 6 hours. Maximum daily dosage should not exceed 75 mg.ElderlyInitially a third to half the adult dose. The physician should then use their clinical judgement to obtain control.IntramuscularAdults25 mg initially, then 25 - 50 mg every 3 - 4 hours until vomiting stops, then drug to be taken orally.ChildrenUnder 1 Year: Do not use unless need is life saving.1 - 5 Years: 0.5 mg/kg 6 - 8 hourly. It is advised that maximum daily dosage should not exceed 40 mg.6-12 Years: 0.5 mg/kg every 6 - 8 hours. It is advised that maximum daily dosage should not exceed 75 mg.ElderlyFor oral use only.

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