Metronidazolum - the description, contraindications, application

The latin name: Metronidazole

Metronidazole Pharmacological groups: Other synthetic anti-infectives

Metronidazole Working substance: Metronidazole

Metronidazole Application: the Amebiasis, a trichomoniasis, a lambliasis, intraabdominal infections (a peritonitis, an abscess), mephitic gangrenes of bones and joints, skins and soft tissues, female genitals (an endometritis, a tubo-ovarian abscess), the CNS (a meningitis, an abscess of a brain), the bottom respiratory paths (a pneumonia, an empyema, an abscess mild), an endocarditis, a pseudomembranous colitis, Helicobacter pylori, an alcoholism, prophylaxis of a postoperative mephitic gangrene. For external and local application: pink and vulgar acnes, it is long not healing wounds, trophic ulcers.

Metronidazole Contraindications: Hypersensitivity, pregnancy, a feeding a breast (for the period of treatment it is necessary to stop thoracal feeding), children's age (excepting cases of an amebiasis).

Metronidazole Restrictions to application: Diseases of a liver with infringement of its functions (the cumulation is possible), the central and peripheric nervous system.

Metronidazole Side effects: the Nausea, a vomiting, an abdominal pain, a diarrhea, unpleasant metal smack, a headache, a giddiness, syncopal conditions, an ataxia, infringements of consciousness, epileptic attacks, a neutropenia (leukopenia), erythematic rashes, a dermal itch, a staining of urine in dark color, allergic reactions, a thrombophlebitis (after intravenously introduction).

Metronidazole Interaction: Strengthens effects of indirect anticoagulants and salts of a lithium. Phenytoinum and Fenobarbitalum reduce action (due to activation of microsomal system of a liver and acceleration of a metabolism and deducing), and Cimetidinum rises (oppresses enzymatic systems of a liver and as consequence, retards a biotransformation). It is incompatible with alcohol (at collateral reception develops disulfiramlike a set of symptoms).

Metronidazole Overdosage: Signs: a nausea, a vomiting, an ataxia, in serious cases - a peripheric neuropathy and epileptic attacks. Treatment: symptomatic; the specific antidote is absent.

Metronidazole Way of application and dose: Inside, during time or after meal. An amebiasis: the adult - on 600-800 mg 3 times day within 8-10 days; to children - 35-50 mg/kg/day, in 3 receptions within 8-10 days. A trichomoniasis: the adult - inside, on 400 mg 2 times day within 5-8 days (if necessary a repeated course through 4-6 weeks) or are single-pass 2,0 g or 250 mg 2 times day within 10 days; simultaneous treatment of both partners is carried out. To children: 2-5 years - 250 milligram/day, 5-10 years - 250-375 milligram/day, are more senior than 10 years - 500 milligram/day inside, thus a daily dose divide into 3 receptions. A lambliasis: the adult - on 400 mg 3 times day within 5 days or on 250 mg 2 times day within 10 days; to children: 2-5 years - 250 milligram/day, 5-10 years - 250-375 milligram/day, are more senior than 10 years - 500 milligram/day inside, in 3 receptions. After end of treatment through 2-3 month control research on completeness of treatment is manufactured. Helicobacter pylori: on 500 mg 3 times day within 7 days, are necessary in a combination with other. Drugs. A mephitic gangrene: the adult - on 400 mg 3 times day within 7-10 days; to children till 12 years - on 7,5 mg / kg 3 times day. In serious cases the drug is entered parenteral (is intravenously trickling) adult 500 mg in 100 ml of a dissolvent, to children - at the rate of 7,5 mg / kg in the same quantity of a dissolvent. The infusion is carried out with rate of 5 mls / mines with intervals with 8 h. For prophylaxis of development of a postoperative mephitic gangrene: in 1 day after operation - 1 g of a drug single-passly, further on 200 mg 3 times day within 7 days. An alcoholism: inside, on 0,5 g/day during 6 (no more) than months. Intravaginal: 500 mg for the night within 10 days. Outwardly: apply 2 times day, the dose is positioned individually.

Metronidazole Trading names of drugs with working substance Metronidazole:
(Aquametro) Metronidazolum (Rosamet) -Metronidazolum (Apo-Metronidazole) Metronidazolum (Metronidazole Nycomed) Klionum (Klion) Metronidazolum - (Metronidazol-AKOS) Trichazolum (Trichazol) (Metrogyl) Metronidazolums - dews (Metronidazol-Ros) (Trichobrol) (Metrozol) Metronidazolum - (Metronidazol-Rusphar) Trichopolum (Trichopol) (Metrolacare) Metronidazolum - Flagylum (Flagyl) (Metron) Metronidazolum - (Metronidazole-Teva) the Efloranum (Efloran) Metronidazolum (Metronidazol) Metronidazolum - (Metronidazol-Farkos) Metronidazolum intravenously Brown (Metronidazole i.v. Braun) Metronidazolum of a tablet of 0,25 g (Tabulettae Metronidazoli 0,25 g)