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Medical Information:
Treating high blood pressure. It may also be used for other conditions as determined by your doctor.
Valsartan/Hydrochlorothiazide is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels. Exactly how the diuretic works to decrease blood pressure is unknown, but it helps the kidneys to eliminate fluid and sodium from the body.
Valsartan :Antagonizes the effect of angiotensin II (vasoconstriction and aldosterone secretion) by blocking the angiotensin II receptor (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP.
Hydrochlorothiazide Increases chloride, sodium, and water excretion by interfering with transport of sodium ions across renal tubular epithelium.