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PANIMUN BIORAL (Neoral, Cyclosporine, Gengraf, Sandimmune)	Used to prevent rejection of kidney, liver, and heart transplants. Cyclosporine and cyclosporine (modified) are used with other medications to prevent transplant rejection (attack of the transplanted organ by the transplant recipient's immune system) in people who have received kidney, liver, and heart transplants. Cyclosporine (modified) is also used alone or with methotrexate (Rheumatrex) to treat the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints) in patients whose symptoms were not relieved by methotrexate alone. Cyclosporine (modified) is also used to treat psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in certain patients who have not been helped by other treatments. Cyclosporine and cyclosporine (modified) are in a class of medications called immunosuppressants. They work by decreasing the activity of the immune system.How should this medicine be used? Cyclosporine and cyclosporine (modified) both come as a capsule and a solution (liquid) to take by mouth. Cyclosporine is usually taken once a day. Cyclosporine (modified) is usually taken twice a day. It is important to take both types of cyclosporine on a regular schedule. Take cyclosporine or cyclosporine (modified) at the same time(s) each day, and allow the same amount of time between doses and meals every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cyclosporine or cyclosporine (modified) exactly as directed. Do not take more or less of the medication or take it more often than prescribed by your doctor.Your doctor will probably adjust your dose of cyclosporine or cyclosporine (modified) during your treatment. If you are taking either type of cyclosporine to prevent transplant rejection, your doctor will probably start you on a high dose of the medication and gradually decrease your dose. If you are taking cyclosporine (modified) to treat rheumatoid arthritis or psoriasis, your doctor will probably start you on a low dose of the medication and gradually increase your dose. Your doctor may also decrease your dose if you experience side effects of the medication. Tell your doctor how you are feeling during your treatment.Cyclosporine (modified) helps control the symptoms of psoriasis and rheumatoid arthritis, but does not cure these conditions. If you are taking cyclosporine (modified) to treat psoriasis, it may take 2 weeks or longer for your symptoms to begin to improve, and 12-16 weeks for you to feel the full benefit of the medication. If you are taking cyclosporine (modified) to treat rheumatoid arthritis, it may take 4-8 weeks for your symptoms to improve. Continue to take cyclosporine (modified) even if you feel well. Do not stop taking cyclosporine (modified) without talking to your doctor. Your doctor may decrease your dose gradually.You may notice an unusual smell when you open a blister card of cyclosporine capsules. This is normal and does not mean that the medication is damaged or unsafe to use.Cyclosporine (modified) oral solution may gel or become lumpy if it is exposed to temperatures below 68 °F. You can use the solution even if it has gelled, or you can turn the solution back to a liquid by allowing it to warm to room temperature (77° F).Cyclosporine and cyclosporine (modified) oral solution must be mixed with a liquid before use. Cyclosporine (modified) oral solution may be mixed with orange juice or apple juice but should not be mixed with milk. Cyclosporine oral solution may be mixed with milk, chocolate milk, or orange juice. You should choose one drink from the appropriate list and always mix your medication with that drink.
SANDIMMUN NEORAL (Cyclosporine, Gengraf, Sandimmune)
CYCLOPHIL ME ( Sandimmune, Neoral/ Gengraf, Generic Cyclosporine )	This medication is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine is also used to treat severe rheumatoid arthritis and a certain skin condition (severe psoriasis). Cyclosporine belongs to a class of drugs known as immunosuppressants. It works by slowing down your body's defense system (immune system) to prevent your body from rejecting a transplanted organ, further damaging your joints (in rheumatoid arthritis patients), or further damaging your skin (in psoriasis patients). For the treatment of psoriasis or arthritis, it is generally used to treat people who cannot take other medications or have not found relief from other treatments. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to prevent rejection in other types of organ transplants (e.g., cornea, pancreas) or bone marrow transplant. It may also be used to treat other conditions that may be helped by affecting the immune system (e.g., Crohn's disease). How to use Cyclosporine Oral Take this medication by mouth, usually twice daily at the same times each day, or take as directed by your doctor. You may take this medication with or without food. However, it is important to choose one way and take every dose the same way. If you take this medication with food, eat the same amount and type of food each time you take the medication. Swallow this medication whole. Do not crush or chew the capsules. Dosage is based on your medical condition, cyclosporine blood level, kidney function, and response to therapy. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit products can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. This medication works best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. If you are taking this drug to treat arthritis, it may take 4-8 weeks to notice improvement, and up to 4 months for the full benefit. If you are taking this drug to treat psoriasis, it may take 2-4 weeks to notice improvement, and up to 4 months for the full benefit. Your dose will slowly be increased during your therapy with this drug. Inform your doctor if your condition does not improve after 6 weeks of taking the highest recommended dose. If you are taking this medication to treat psoriasis, do not take it continuously for longer than one year unless directed to do so by your doctor. Cyclosporine Oral is used to treat the following: Severe Psoriasis that is Resistant to Treatment, Rheumatoid Arthritis, Body's Rejection of a Transplanted Organ, Prevent of Transplant Rejection, Prevent Kidney Transplant Rejection, Prevention of Liver Transplant Rejection, Prevention of Cardiac Transplant Rejection Cyclosporine Oral may also be used to treat: Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia, Prevention of Lung Transplant Rejection, Incompatibility Reaction Following Bone Marrow Transplant, Treatment to Prevent Reaction After Bone Marrow Transplant
IMUSPORIN ( Neoral, Sandimmune, Gengraf, Generic Cyclosporine )	Cyclosporine (SYE-kloe-spor-een) Helps to prevent organ rejection after a kidney, liver, or heart transplant. Also treats rheumatoid arthritis and psoriasis. When This Medicine Should Not Be Used: You should not use this medicine if you have had an allergic reaction to cyclosporine, or if you have certain kidney problems, uncontrolled high blood pressure, or cancer. How to Use This Medicine: Capsule, Liquid Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. Take this medicine at the same time(s) every day. You may take this medicine with or without food, just be sure to take it the same way every day in relationship to your meals. It is important that you do not stop taking this medicine suddenly, unless your doctor tells you to. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. This medicine may be used with other medicines that prevent organ rejection. Take all other medicines your doctor prescribed as part of your combination treatment. To measure the oral liquid, use the measuring device provided with the medicine, or use a marked measuring spoon, oral syringe, or medicine cup. Mix the oral liquid in a drinking glass, not a plastic cup. You can mix it with apple or orange juice to make it taste better. Do not mix it with very cold or hot drinks. Stir well, and drink your medicine right away. Rinse the glass with more juice or water and drink that too, so you get all of the medicine. If a dose is missed: If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

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