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Medical Information:

Aricept is used for: Treating mild to moderate dementia (eg, impairment of memory, judgment, and abstract thinking; changes in personality) caused by Alzheimer disease.

Donepezil (doe-NEP-ah-zil) is used to treat the symptoms of mild to moderate Alzheimer's disease. Donepezil will not cure Alzheimer's disease, and it will not stop the disease from getting worse. However, it can improve thinking ability in some patients.

Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning

Aricept is one of the few drugs that can provide some relief from the symptoms of early Alzheimer's disease. (Cognex, Exelon, and Reminyl are others.) Alzheimer's disease causes physical changes in the brain that disrupt the flow of information and interfere with memory, thinking, and behavior.
Aricept is one of a group of drugs called "cholinesterase inhibitors" which is used to treat symptoms in individuals with mild to moderate Alzheimer Disease.

In brains of people with Alzheimer Disease there is a progressive degeneration of nerve cells. Particularly notable is a degeneration of cells which make acetylcholine, a chemical thought to be important for learning and memory. People with Alzheimer Disease have lower brain levels of acetylcholine. Aricept acts by decreasing the activity of acetylcholinesterase, an enzyme whose function is to break down acetylcholine. It is believed that because Aricept reduces the breakdown of acetylcholine, it will lead to an increase in the level of acetylcholine in the brain. The potential beneficial effect could lessen as the disease progresses and when fewer cells are available to make acetylcholine.

How does it help?Aricept is intended to treat symptoms in individuals with mild to moderate Alzheimer Disease. In clinical trials, individuals who took Aricept when compared to individuals who took a placebo (a substance which looks like the drug but has no effect), showed improvement or no further decline in cognition (including memory, orientation, language) and function (including performance of daily activities).

Aricept may take as long as 12 weeks to begin working, and the type of and length of response to this medicine will vary from individual to individual.

What does Aricept not do?Aricept is not a cure for Alzheimer Disease as it does not affect the underlying degenerative process of the disease.

Who should take Aricept?Individuals who have been diagnosed with mild to moderate Alzheimer Disease.

Important! Things to know before taking AriceptYou should tell the doctor if you are allergic to donepezil hydrochloride or piperidine derivatives such as Mycobutin (rifabutin), Ritalin (methylphenidate), Akineton (biperiden HCI), Artane (trihexyphenidyl HCI), Bupivacaine HCI, and Paxil (paroxetine HCI). You should also tell your doctor if you have a condition affecting your heart or your lungs; if you have had seizures; if you have had fainting spells; and if you have a history of peptic ulcers or have an increased risk of developing ulcers (for example, if you are taking non-steroidal anti-inflammatory drugs [NSAIDs] or high doses of acetylsalicylic acid [ASA/Aspirin]).

Aricept should not be used if you are pregnant or breastfeeding.

How do you take Aricept?Take Aricept only as prescribed by your doctor. Never change the dose yourself.

Take Aricept in the evening, just before going to bed. If you experience insomnia (difficulty sleeping), Aricept may be taken in the morning.

Aricept may be taken with or without food.

If you miss taking a dose of Aricept do not worry, just take the next dose when it is due. Do NOT take 2 doses at once.

If you have problems remembering to take medications, it may be necessary to have someone manage this for you.

Aricept is available in a blisterpack to help remind you to take your medication every day. Ask your physician or pharmacist for more details.

This medicine has been prescribed only for you or for the person you are caring for. Never give it to anyone else.

What are the possible side effects?Along with its beneficial effect, Aricept may cause some undesirable reactions. The most common side effects include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue and loss of appetite. In clinical studies these effects were often mild, and generally went away with continued treatment. In clinical studies some patients treated with Aricept experienced fainting. If you feel unwell in any other way or have any symptoms that you do not understand, or find distressing, you should contact your doctor immediately.

What to do if an overdose is takenIf more medication has been taken than what has been prescribed, contact your doctor, hospital emergency department, or the nearest poison control centre immediately.

How to identify AriceptAricept tablets contain donepezil hydrochloride. The 5 mg tablets are white and the 10 mg tablets are yellow.

How do you store Aricept?Keep this medicine in a safe place, out of reach of children.

Keep this medicine in a cool dry place between 15°C and 30°C (59°F and 86°F) and avoid exposure to moisture.

If the doctor decides to stop Aricept treatment, return any leftover medicine to your pharmacist. Keep it only if the doctor tells you to do so.