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Drugs group	Short description
Colospa (Colofac, Generic Mebeverine)	Colospa is manufactured by Duphar, India.COLOSPA is used to relieve thesymptoms of irritable bowelsyndrome, which include, abdominalpain and cramps, bowel spasm,diarrhoea and flatulence.COLOSPA belongs to a group ofmedicines known as antispasmodicagents. COLOSPA is also known as mebeverine hydrochloride.COLOSPA works by relaxing themuscles in the gut, thereby relievingthe symptoms of irritable bowelsyndrome
COLOSPA ( Colofac, Generic Mebeverine )	Category : Antispasmodic; smooth muscle relaxant. Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings Relief of abdominal pain, cramps, bloating and wind, diarrhoea or constipation associated with irritable bowel syndrome.

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