Climara - the description, contraindications, application

The latin name: Climara

Climara Pharmacological groups: Antitumoral hormonal agents and antagonists of Hormonums. Estrogens, gestagens; their homologues and antagonists

Climara Working substance: Estradiol

Climara Application: Oestrogenic failure in a climacteric and after gynecologic operations, a time-lagged puberty at girls, an alopecia at a hyperandrogenism, a hirsutism at a set of symptoms of polycystic ovaries, delicacy of patrimonial activity, an initial biliary cirrhosis of a liver at women, parent bleedings, postcoital contraception, a migraine and prophylaxis of an osteoporosis at women in the fore-menopause period, a cancer of a breast at men and women with metastasises (palliative therapy), a carcinoma of prostatic Ferri lactas (palliative therapy).

Climara Contraindications: Hypersensitivity, a cancer of a uterus, ovaries, lactic Ferri lactas, neoplastic processes, an endometriosis, infringement of functions and tumours of a liver, a diabetes (, with defeat of vessels), a sickemia, a herpes, an otosclerosis with deterioration of hearing, an icterus or a constant itch during the previous pregnancy, a undiagnosed parent bleeding, a thrombophlebitis and thromboembolic conditions (including in an anamnesis), pregnancy, a feeding a breast.

Climara Side effects: the Headache, a giddiness, depression, a migraine, a chorea, infringement of vision (change of curvature of a cornea), rising the HELL, thromboembolisms, a nausea, a vomiting, a pain in epigastric area, a meteorism, a cholestatic hepatitis, a cloelithiasis, parent bleedings, a hyperplasia an endometritis, augmentation of the sizes of a uterus, fibrous changes of a myometrium, a vaginal candidiasis, inspissation and augmentation of a breast, change of a libido, edemas, augmentation of mass of a body, downstroke of tolerance to carbohydrates, attacks of a porphyria, a chloasma, a melanoderma, a contact dermatitis, an itch and a dermahemia (in situ applications of Emplastrum), allergic reactions.

Climara Interaction: the Effect is reduced with narcotic analgesics, tranquilizers, narcosis and antispasmodic drugs, inductors of microsomal enzymes of a liver. Reduces activity of hypotensive, anticoagulating and hypoglycemic agents.

Climara Overdosage: Signs: a nausea, a vomiting and in some cases - parent bleedings. Treatment: maintenance of the vital functions (on a background of a cancellation of a drug).

Climara Way of application and dose: Inside. Initial and secondary oestrogenic failure - 1-2 mg of 1 times day during 3 weeks, then a time-out (1 weeks); the maintenance dose is selected by titration up to minimum efficient. A cancer of prostatic Ferri lactas - 1-2 mg 3 times day; a cancer of a breast at men and women with the remote metastasises - 10 mg 3 times day within not less than 3 months. For prophylaxis of an osteoporosis - 0,5 mg of 1 times day within 23 days, then a five-day time-out. The gel is rendered with 1 time day on a skin on bottom of a forward wall of a stomach, or serially on a right or left breech. An initial dose - 1 g of a gel (1 mg of Oestradiolum). A center dose - 0,5-1,5 g of a gel day. The area of drawing is peer on size to 1-2 palms. Emplastrum render on a skin of 1 times in a weeks. Treatment carry out continuously or 3 week courses with a time-out in 1 weeks. Simultaneously appoint Progesteronum each month within 10-12 days. Intramuscularly, 0,1 % a solution in oil on 1 ml of 1 times in 3-5 days.

Climara Precautionary measures: At long therapy not less often than 1 time one year routine maintenance is necessary.

Trading names of drugs with working substance Estradiol:
(Divigel) (Octodiol) (Oestrogel) (Climara) (Estrofem)