Ciprofloxacin - the description, contraindications, application

The latin name: Ciprofloxacin

Ciprofloxacin Pharmacological groups: Quinolones / fluoroquinolones

Ciprofloxacin Working substance: Ciprofloxacin

Ciprofloxacin Application: Infections of ENTS - BODIES (a center otitis, a sinusitis, a mastoiditis, a tonsillitis, a pharyngitis), the bottom respiratory paths (a bronchitis acute and an exacerbation chronic, a pneumonia, except for pneumococcal, a bronchoectatic disease, a mucoviscidosis), bodies of a small basin (a cystitis, a pyelonephritis, a prostatitis, an adnexitis, a salpingitis, an oophoritis, an endometritis, a glandular abscess, a pelvic peritonitis), skins and soft tissues (infected ulcers, wounds, combustions, infections of external acoustical passage, abscesses, cellulitises), bones and joints (an osteomyelitis, a septic arthritis), venereal (a gonorrhea, a venereal ulcer, a clamidiosis), a belly cavity (a cholic bubble and bile-excreting paths, intraperitoneal abscesses, a peritonitis, a salmonellosis, including a typhoid, a campilobacteriosis, , a shigellosis, a cholera), a bacteriemia, a hematosepsis, serious infections on a background of an immunodeficiency and a neutropenia, prophylaxis of infections at surgical interventions. Locally - infectious - inflammatory diseases of eyes (a conjunctivitis, a blepharoconjunctivitis, a blepharitis, a keratitis, a keratoconjunctivitis, a bacterial helcoma).

Ciprofloxacin Contraindications: Hypersensitivity (including to other fluoroquinolones), deficiency of a glucose 6-phosphate dehydrogenase, children's and teenage age (before the termination of the period of intensive body height), pregnancy, a feeding a breast (for the period of treatment stop).

Ciprofloxacin Side effects: Nausea, vomiting, infringement of appetite, diarrhea, constipation, pseudomembranous colitis, epigastric and transabdominal pains, discomfort in a stomach, a hiccup, ulcers, dryness and morbidity of a mucosa of an oral cavity, a meteorism, bleedings in the GASTROINTESTINAL TRACT, a pancreatitis, a cholestatic icterus, a hepatitis, a necrosis of cells of a liver, a headache, a giddiness, exaltation, sensation of anxiety, a sleeplessness, dreadful dreams, depression, phobias, feeling of weariness, infringement of vision (a chromatopsia, a diplopia, a nystagmus, a pain in eyes), taste, an olfaction, a sonitus, a transitional hearing disorder, change of mood, infringement of gait, rising of intracranial pressure, a paresthesia, a sweating, an ataxia, a tremor, cramps, a toxic psychosis, a paranoia, hallucinations, a hyperpegmentation, an eosinophilia, a fever, a photosensitization, a leukopenia, a leukocytosis, an anemia, a thrombocytopenia, a thrombocytosis, change of a level of a thrombinogen, transitional rising of hepatic transaminases, Alkaline phosphatase, creatinine, ureas, serumal triglycerides, a glucose, a potassium, a bilirubin, a hypotonia, a syncope, a cardiovascular collapse, arrhythmias, a cerebral clottage, a Bouveret's disease, a pulmonary embolism, a dyspnea, a bronchospasm, an exudate in a pleura, an arthralgia, myalgias, a tendovaginitis, an often emiction, a crystalluria, a hematuria, a cylindruria, a polyuria, a proteinuria, an acidosis, an ischuria, a hemorrhagic cystitis, a nephritis, a vaginitis, a gynecomastia, an eruption, petechias, bubbles, papules, a dermal vasculitis, Stevens set of symptoms - Johnson, a Lyell's disease, a polymorphic exudative erythema, an exfoliative dermatitis, a dermal itch, an edema of labiums, persons, necks, conjunctivas, extremities, a Quincke's disease, a urticaria, an anaphylactic shock, a dysbacteriosis, a candidiasis; in situ intravenously introductions - a pain, feeling of a burning sensation, a phlebitis.

Ciprofloxacin Interaction: Activity grows at a combination to antibiotics, aminoglycosides, Vancomycinum, a clindamycin, Metronidazolum. The sucralfate, drugs of a bismuth, the antacids containing ions of aluminium, magnesium or calcium, Cimetidinum, , vitamins with trace substances, Ferri lactas Zinci sulfas, Zincum, , purgatives reduce an adsorption (it is recommended to apply 2 h prior to or in 4 h after these drugs). A probenecid, fortify in a blood. Reduces Cl and rises a level in plasma of a coffeine, Aminophyllinum and Theophyllinum (the probability of development of side effects accrues). Strengthens effect of warfarin, etc. peroral anticoagulants (extends a bleeding time). Enlarges a nephrotoxicity a cyclosporine, risk of rising of an excitability of the CNS and convulsive reactions on a background of the NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. The drugs, rendering alkaline I wet (Citrases, a sodium Sodium hydrogenum, inhibitors of a carbonic anhydrase), reduce solubility (the probability of a crystalluria grows). We compose to infusion solutions: 0,9 % of a sodium of Sodium chloridum, 5 and 10 % of a glucose, 10 % of fructose, 5 % of the glucose, containing 0,225 or 0,45 % of a sodium of Sodium chloridum. It is incompatible with the solutions having pH is higher 7.

Ciprofloxacin Overdosage: Signs: specific signs are not present. Treatment: the gastric lavage, application of vomitive drugs, introduction of a plenty of a liquid, creation of acid reaction of urine, is padding - a haemodialysis and a peritoneal dialysis; all actions are carried out on a background of maintenance of the vital functions.

Ciprofloxacin Way of application and dose: Inside (not chewing and washing down with enough of a liquid) on 250 mg (at serious infections - on 500-750 mg) 2-3 times day. Intravenously - on 200 mg (at serious infections - 400 mg) 2 times day. Duration of an infusion makes 30 mines at a dose of 200 mg and 60 mines - at a dose of 400 mg. Course of treatment - from 7-14 days at acute infections up to 4-6 weeks and more at an osteomyelitis and . At an acute gonorrhea - 100 mg are single-pass inside of 250-500 mg or intravenously. For prophylaxis of infections after surgical interventions for 30-60 mines before operation inside of 500-750 mg or intravenously - 200-400 mg, at long operations carry out repeated introduction in 4 h. To patients with the expressed infringement of function of kidneys a daily dose reduce twice, to elderly patients - on 1/3. Locally: on 1-2 drop in an eye each 4 h, at serious infections - on 2 drop in an eye each hour.

Ciprofloxacin Precautionary measures: With care appoint at a pathology of the CNS in an anamnesis: mental diseases, an epilepsy, dropping of a convulsive threshold, an apoplexy, a serious atherosclerosis of vessels of a brain (risk of infringement of a blood supply, an insult), in advanced age, at serious infringements of function of kidneys and a liver (the control of concentration over a blood plasma is necessary). During treatment it is necessary to avoid solar and the ULTRAVIOLET irradiation, intensive exercise stresses to supervise a drinking regimen, pH urine. Can depress rate of psychomotor reactions, it is especial on a background of alcohol that it is necessary to take into account to the patients working with potentially dangerous mechanisms or managing vehicles. If the serious diarrhea develops, it is necessary to exclude a pseudomembranous colitis (at which the Ciprofloxacin counterindicatives). Simultaneous intravenously introduction of barbiturates demands the control of function of cardiovascular system (the HELL, indexs the ELECTROCARDIOGRAM). To teenagers till 18 years it is appointed only in case of a resistance of the originator to other chemotherapeutic drugs.

Trading names of drugs with working substance Ciprofloxacin:
(Aquacipro) (Ciloxan) (Cipropan) (Alcipro) (Ciplox) (Ciprosun) the -Ciprofloxacin (Vero-Ciprofloxacin) (Ciprinol) (Ciprosin) (Ificipro) (Ciprobay) the Ciprofloxacin (Ciprofloxacin) (Quintor) (Ciprobid) the Ciprofloxacin - (Ciprofloxacin-AKOS) -250 (Quintor-250) (Ciprobrin) the Ciprofloxacin - (Ciprofloxacin-FPO) -500 (Quintor-500) 250 (Ciprovin 250) the Ciprofloxacin a hydrochloride (Ciprofloxacini hydrochloridum) (Lyproquin) (Ciprodar) the Ciprofloxacin of a hydrochloride the tablets covered with an environment, 0,25 g (Tabulettae Ciprofloxacini hydrochloridi obductae 0,25 g) (Medociprin) (Ciprodox) (Citeral) the Microphlox (Microflox) (Ciprolacare) (Cifloxinal) (Procipro) (Ciprolet) (Cifran) (Recipro) (Ciprolone) ODES (Cifran OD) (Sifloks) (Cipromed) (Ceprova) (Cipronat)