PARAXIN ( Chloromycetin, Generic Chloramphenicol )
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Chloramphenicol is primarily bacteriostatic. It binds to the 50S subunit of the ribosome, thereby inhibiting bacterial protein synthesis.Chloramphenicol has a wide spectrum of activity against gram-positive and gram-negative cocci and bacilli (including anaerobes), Rickettsia , Mycoplasma, and Chlamydia and Chlamydophila. Because of bone marrow toxicity, the availability of alternative antibiotics, and the emergence of resistance, chloramphenicol is no longer a drug of choice for any infection, except serious infections due to a few multidrug-resistant pathogens that retain susceptibility to this antibiotic. However, outcomes of chloramphenicol treatment of meningitis caused by relatively penicillin-resistant pneumococci have been discouraging. |
