Chloramfenicolum - the description, contraindications, application

The latin name: Chloramphenicol

Chloramphenicol Pharmacological groups: Amphenicols

Chloramphenicol Working substance: Chloramphenicol

Chloramphenicol Application: the Typhoid, a sapropyra, a paratyphoid, a brucellosis, a rickettsiosis, a tularemia, a dysentery, a whooping-cough, a clamidiosis, a meningitis, an abscess of a brain, a pneumonia, a sepsis, an osteomyelitis, pyoinflammatory diseases of a skin (furuncles, anthraxes), the purulent wounds, infected combustions, nipple cracks at feeding mothers, infectious diseases of eyes (a conjunctivitis, a keratitis, a blepharitis, a trachoma).

Chloramphenicol Contraindications: Hypersensitivity, diseases of bodies of a hemopoiesis, the acute intermittent porphyria, the expressed infringements of function of kidneys and a liver, deficiency -6-, a psoriasis, an eczema, fungic diseases of a skin, pregnancy, a feeding a breast (refusal of thoracal feeding is obligatory), early children's age (the first months of life).

Chloramphenicol Restrictions to application: Diseases of cardiovascular system, predilection to allergic diseases.

Chloramphenicol Side effects: the Nausea, a vomiting, a fluid chair, a boring of mucosas of a mouth, a fauces, a leukopenia, a thrombocytopenia, a reticulocytopenia, , an agranulocytosis, an aplastic anemia, psychomotor frustration, infringement of consciousness, a delirium, visual and acoustical hallucinations, a paralysis of eyeglobes, infringement of taste, downstroke of sensory acuity and vision, a dysbacteriosis, a superinfection, a cardiovascular collapse (at children till 1 year), a dermatitis, allergic reactions (a dermal eruption, a urticaria, a Quincke's disease).

Chloramphenicol Interaction: Cycloserinum strengthens neuro, Ristomycinum. Fenobarbitalum accelerates a biotransformation, reduces concentration and duration of effect. Oppresses a metabolism of Tolbutamidum, Chlorproramidum, derivants (enlarges hypoglycemic and properties). Erythromycin, Oleandomycinum, Nistatinum, Levorinum rise antibacterial activity, salts of a benzylpenicillin - reduce. It is incompatible with cytostatics, Sulfanilamidums, derivants of pyrazyl ketone, the phenytoin, barbiturates, alcohol.

Chloramphenicol Way of application and dose: Inside: for 30 mines up to meal (in case of a nausea and a vomiting - in 1 h after meal) and locally. A regimen of dosing individual. A single dose for adults - 0,25-0,5 g; diurnal - 2,0 g (in especially serious cases - up to 4 g, under strict observation of the doctor and the control over a condition of a blood and functions of kidneys). A daily dose divide into 3-4 receptions. The single dose for children till 3 years - 10-15 mg / kg of mass of a body, 3-8 years - on 0,15-0,2 g, is more senior than 8 years - on 0,2-0,3 g; accept 3-4 times day. Course of treatment - 7-10 days (under indications, under condition of a good acceptability - up to 2 weeks). Locally, skin: 5-10 % Linimentum; render on the damaged sites of a skin immediately or, having impregnated Linimentum, sterile gauze napkins. Application with an occlusive bandage is possible. Dressings carry out in 1-3 days (less often - in 4-5 days) before complete weeding a wound. Conjunctival: At treatment of pyoinflammatory diseases of eyes apply 1 % Linimentum or 0,25 % an aqueous solution.

Chloramphenicol Special indicatings: At intake it is necessary to carry out the control of a pattern of a peripheric blood on a regular basis. At treatment of nipple cracks it is not required from feeding mothers of the termination of thoracal feeding of newborns.

Trading names of drugs with working substance Chloramphenicol:
L-(racemic) Chloramfenicolum (D, L-(racemic) Cloramphenicol) Levomycetinum - (Laevomycetin-UBF) the Synthomycin - (Synthomycin-Rusphar) ?-? Chloramfenicolum (D-L Chloramphenicol) Levomycetinum of a sodium a succinate (Laevomycetini Natrio-succines) the Synthomycin Linimentum (Linimentum Synthomycini) -CHLORAMFENICOLUM (dl-Chloramphenicol) Levomycetinum a solution of 0,25 % (Solutio Laevomycetini 0,25 %) Suppositories vaginal with a synthomycin of 0,25 g (Suppositoria vaginalia cum Synthomycino 0,25 g) Levomycetinum (Laevomycetinum) Levomycetinum a solution alcohol (Solutio Laevomycetini spirituosa) Chloramfenicolum (Chloramphenicol) Levomycetinum capsular (Laevomycetinum in capsiles) Levomycetinum a solution of alcohol 0,25 % (Solutio Laevomycetini spirituosa 0,25 %) Chloramfenicolum left (Chloramphenicol Levo) Levomycetinum capsular 0,25 g (Laevomycetinum in capsilis 0,25 g) Levomycetinum a solution alcohol 1 % (Solutio Laevomycetini spirituosa 1 %) Chloramfenicolum sterile (Chloramphenicol) Levomycetinum - ( Laevomycetin-AKOS) Levomycetinum a succinate soluble (Laevomycetini succines soluble) Chloramfenicolum of a sodium a succinate sterile (Chloramphenicol sodium succinate) Levomycetinum - (Laevomycetin-KMP) Levomycetinum of a tablet (Tabulettae Laevomycetini) Levomycetinum - (Levomycetin-Rusphar) the Synthomycin (Synthomycinum)