Ceftriaxone - the description, contraindications, application

The latin name: Ceftriaxone

Ceftriaxone Pharmacological groups: Cephalosporins

Ceftriaxone Working substance: Ceftriaxone

Ceftriaxone Application: Infections of top and bottom respiratory paths, -BODIES (including an acute and chronic bronchitis, a pneumonia, an abscess mild, an empyema of a pleura), skins and soft tissues, genitourinary bodies (a pyelitis, an acute and chronic pyelonephritis, a cystitis, a prostatitis, an epididymitis, etc.), joints, wound, maxillofacial area, bodies of a belly cavity (a peritonitis, cholic paths and the GASTROINTESTINAL TRACT), a uncomplicated gonorrhea, including caused by the microorganisms allocating a penicillinase, a sepsis and a bacterial hematosepsis, an osteomyelitis, a bacterial meningitis and an endocarditis, a venereal ulcer and a lues, illness Lima (spirochetosis), a typhous fever, a salmonellosis and , infections at patients with the weakened immunity, prophylaxis of postoperative infectious complications.

Ceftriaxone Contraindications: Hypersensitivity (including to other cephalosporins, Penicillinums, carbapenemses), pregnancy (I a trimester), a feeding a breast.

Ceftriaxone Restrictions to application: Hepatonephric failure, bleedings and diseases of the GASTROINTESTINAL TRACT in an anamnesis, especially nonspecific ulcerative colitis, an enteritis or a colitis connected to application of antibacterial drugs; a hyperbilirubinemia at newborn and premature children.

Ceftriaxone Application at pregnancy and a feeding a breast: It counterindicative in I a trimester of pregnancy. For the period of treatment it is necessary to stop thoracal feeding.

Ceftriaxone Side effects: the Diarrhea, a nausea, a vomiting, a constipation, a meteorism, an abdominal pain, infringement of taste, a stomatitis, a glossitis, a pseudomembranous colitis, transitional rising of activity of transaminases, less often - an alkaline phosphatase or a bilirubin, a cholestatic icterus, rising of a creatinine, a glucosuria, presence of cylinders in urine, a hematuria, an oliguria, an anuria, a thrombocytosis, a thrombocytopenia, a leukopenia, it is rare - a hemocatheretic anemia, a neutropenia, a lymphopenia, downstroke of a level of plasma factors of coagulation of a blood (II, VII, IX, X), elongation a prothrombin time, a headache, a giddiness, a nasal bleeding, a dysbacteriosis, a superinfection, a candidiasis, allergic reactions: an eruption, an itch, a urticaria, a fever or agues, a serum disease, a bronchospasm, an eosinophilia, a polymorphic exudative erythema, Stevens set of symptoms - Johnson and an anaphylactic shock; local reactions: a pain or an infiltrate in situ injections, it is rare - a thrombophlebitis after intravenously introduction.

Ceftriaxone Interaction: Strengthens it (is relative) effect of aminoglycosides concerning many Gram-negative microorganisms. The NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, etc. inhibitors of aggregation of thrombocytes enlarge probability of a bleeding, loopback diuretics and nephrotoxicity drugs - infringements of functions of kidneys. It is pharmaceutic incompatible with other antimicrobial agents.

Ceftriaxone Way of application and dose: Intramuscularly and intravenously; to adults and children than 12 years of 1 times of 1-2 g day, if necessary - up to 4 g (it is desirable in 2 introductions through 12 ) are more senior. Duration of treatment depends on a kind of an infection and gravity of a condition. After disappearance of signs and normalization of temperature it is recommended to continue application within not less than three days. At a uncomplicated gonorrhea enter intramuscularly 0,25 g single-passly. For newborns up to 2 weeks the daily dose makes 20-50 mg / kg, children from 3 weeks till 12 years - 50-80 mg / kg day, in 2 introductions. The daily dose should not exceed 2 g, at premature children - 50 mg / kg, prophylaxis of postoperative infections - 1 g single-passly for 1/2 - 2 h before operation. Intravenously as an infusion during 15-30 mines in concentration of 10-40 mg / ml. For intravenously bolus introduction a drug dissolve in sterile water for injections in the ratio 1:10, for intramuscularly introduction - in 1 % a solution of Lidocainum (0,5 g of a powder in 2 ml or 1 g - in 3,5 ml).

Ceftriaxone Precautionary measures: At a combination of renal and hepatic failure and at the patients who are taking place on a haemodialysis, correction of a dose and monitoring of concentration in plasma (the maintenance in a blood is recommended to be supervised batchly and at isolated infringement of function of a liver or kidneys) is required. At an arterial hypertension and infringement of water-electrolytic balance it is necessary to check a level of a sodium in plasma. In case of long purpose performance of the cytologic analysis of a blood is necessary, it is necessary to mean possible development of a dysbacteriosis. With care apply at newborns with a hyperbilirubinemia, premature children, patients, susceptible to allergic reactions. By the elderly and weakened patient purpose of phthiocol can be demanded.

Trading names of drugs with working substance Ceftriaxone:
(Azaran) (Rocephin) (Ceftriaxone) (Biotrakson) (Stericef) a sodium (Ceftriaxone sodium) (Ificef) (Tercef) a sodium sterile (Cefuroxime sodium sterile) (Lendacin) (Torocef) Prothose (Ceftriaxone Protech) (Lifaxon) (Triaxone) - (Ceftriaxone-AKOS) (Loraxon) (Troxon) - (Ceftriaxone-Darnitsa) Megion (Megion) (Cefaxone) - (Ceftriaxone-KMP) (Medaxon) (Cefatrin) - (Ceftriaxone-PNITIA) (Novocef) (Cefogram) sodic salt (Ceftriaxone sodium) (Oframax) (Cefson) sodic salt sterile (Cefuroxime sodium salt sterile) (Rocepherin) (Ceftriabolum)