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Carvedilol - the description, contraindications, applicationThe latin name: CarvedilolCarvedilol Pharmacological groups: the Alpha and beta - adrenoblockers Carvedilol Working substance: Carvedilol Carvedilol Application: the Arterial hypertension, a stenocardia of a strain, a chronic heart failure. Carvedilol Contraindications: the Hypersensitivity, a decompensated heart failure (IV function class on NYHA), the expressed bradycardia, AV blockade II-III of a degree, sinuatrial blockade, a set of symptoms of delicacy of sinus unit, a shock, chronic obstructive diseases mild, a bronchial asthma, serious defeats of a liver, pregnancy, a feeding a breast (for the period of treatment refusal of thoracal feeding is necessary), children's and youthful age (till 18 years). Carvedilol Side effects: the Giddiness, a headache, delicacy, syncopal conditions (rarely and, as a rule, only in the beginning of treatment), frustration of dream, depression, paresthesias, a bradycardia, infringement AV of conduction, a postural hypertonia, edemas, deterioration of a peripheric circulation, progressing of a heart failure, acute renal failure, an obstruction of a nose, bronchospasmodic reactions, a nausea, abdominal pains, a diarrhea, an obstipation, a vomiting, pains in extremities, a xeroma, rising of a level of transaminases in a blood, a thrombocytopenia, a leukopenia, a hyperglycemia, augmentation of mass of a body, dermal allergic rashes. Carvedilol Interaction: At application together with cardiac glycosides or diltiazems probably retardation AV of conduction. Enlarges the maintenance of digoxin in Serum of a blood. Anesthetics strengthen negative inotropic and hypotensive effects of a Carvedilol. Fenobarbitalum, Rifampicinum accelerate a metabolism and reduce concentration in plasma. Diuretics and inhibitors will potentiate a hypotonia. It is incompatible with intravenously introduction of antagonists of calcium. Carvedilol Overdosage: Signs: the expressed hypertension (a garden of a hg of 80 mm and is lower), a bradycardia (less than 50 impacts in mines), a heart failure, a cardiogenic shock, infringement of respiratory function. Treatment: cardiotonics, monitoring of function of cardiovascular and respiratory systems, functions of kidneys. Carvedilol Way of application and dose: Inside. At an arterial hypertension - 25-50 mg of 1 times day (the initial dose in the first 2 day can make 12,5 mg), at a stenocardia - on 25-50 mg 2 times / day, at a chronic heart failure - on 12,5-25 mg 2 times / day (it is maximum - up to 100 milligram/day). Carvedilol Precautionary measures: With care it is necessary to apply at persons of advanced age (half doses are appointed), at a diabetes (masks clinical displays of a hypoglycemia), recent deterioration of current of a heart failure. In all cases treatment begin low doses with subsequent sluggish their selection up to efficient. At progressing a heart failure on a background of treatment it is recommended to increase a dose of diuretics, and at renal failure a dose control depending on a function condition of kidneys. For prevention of development of a withdrawal the dose should be reduced gradually. At the combined therapy of a heart failure in case of the expressed dropping the HELL is recommended to lower originally a dose of diuretics or inhibitors . During treatment the use of alcohol is excluded. With care appoint to patients which work is connected to necessity of an enhanced attention and reaction rate. Trading names of drugs with working substance Carvedilol: (Acridilole) the Carvedilol (Carvedilol) (Coriol) (Dilatrend) (Cardivas) (Talliton) |
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