Capoten - the description, contraindications, application

The latin name: Capoten

Capoten Pharmacological groups: Inhibitors

Capoten Working substance: Captopril

Capoten Application: the Arterial hypertension (mono-and the combined therapy), a stagnant heart failure, a cardiomyopathy, infringement of function of a left ventricle at stable state at patients after the transferred myocardial infarction, a diabetic nephropathy on a background of a diabetes of type 1 (at an albuminuria more than 30 milligram/day).

Capoten Contraindications: Hypersensitivity, presence of anamnestic data on edematization at previous purpose of inhibitors , a hereditary or idiopathic Quincke's edema, an initial hyperaldosteronism, pregnancy, a feeding a breast.

Capoten Restrictions to application: the Estimation of a parity risk - advantage is necessary in the following cases: a leukopenia, a thrombocytopenia, an aortal stenosis or other obstructive changes complicating outflow of a blood from heart; a hypertrophic cardiomyopathy with low cardiac exhaust; the expressed infringements of function of kidneys; a bilateral stenosis of renal arterias or a stenosis of an arteria of a unique kidney; presence of the replaced kidney; a hyperkalemia; children's age.

Capoten Application at pregnancy and a feeding a breast: It counterindicative at pregnancy. For the period of treatment it is necessary to stop thoracal feeding.

Capoten Side effects: From the side of nervous system and sense organs: fatigability, a giddiness, a headache, oppression of the CNS, a sleepiness, a confusion of consciousness, depression, an ataxia, cramps, sensation of a numbness or a pricking in extremities, infringements of vision and-or an olfaction. From the side of cardiovascular system and a blood (a hemopoiesis, a hemostasis): a hypotension, including orthostatic, a stenocardia, a myocardial infarction, infringement of a rhythm of heart (atrial tachy-or a bradycardia, a ciliary arrhythmia), palpitation, acute infringement of a cerebral circulation, peripheric edemas, a lymphadenopathy, an anemia, a pain in a thoracal cell, a thromboembolism of a pulmonary arteria, a neutropenia, an agranulocytosis (0,2 % - at patients with infringement of function of kidneys, 3,7 % - on a background of collagenouses), a thrombocytopenia, an eosinophilia. From the side of respiratory system: a bronchospasm, a short wind, an interstitial pneumonitis, a bronchitis, barren dry tussis. From the side of bodies of the GASTROINTESTINAL TRACT: Anorexia, infringement of taste, stomatitis, cankers of a mucosa of an oral cavity and stomach, xerostomia, glossitis, difficulty of a swallowing, nausea, vomiting, dyspepsia, meteorism, abdominal pain, constipation or diarrhea, pancreatitis, defeat of a liver (a cholestasia, a cholestatic hepatitis, a hepatocellular necrosis). From the side of genitourinary system: infringement of functions of kidneys, an oliguria, a proteinuria, an impotency. From the side of integuments: an erubescence of the person, an eruption, an itch, an exfoliative dermatitis, a toxic epidermal necrolysis, a pempigus, surrounding deprive, an alopecia, a photodermatitis. Allergic reactions: Stevens set of symptoms - Johnson, a urticaria, a Quincke's edema, an anaphylactic shock, etc. Other: a fervescence, a fever, a sepsis, an arthralgia, a hyperkalemia, a gynecomastia, a serum disease, rising of the maintenance in bloods of hepatic enzymes, a urea nitrogen, an acidosis, positive reaction at carrying out of the paste for antibodies to a nuclear antigene.

Capoten Interaction: Will potentiate hypoglycemic effect of peroral antidiabetic drugs, strengthens possible hypotensive effect of anesthetics. Reduces the secondary hyperaldosteronism and a hypokalemia caused by diuretics. Rises concentration of a lithium and digoxin in plasma. Effects strengthen other antihypertensives, including beta - adrenoblockers, including at a systemic adsorption from ophthalmologic medicinal forms, diuretic agents, Clonidinum, narcotic analgesics, antipsychotic agents, alcohol, weaken - estrogens, the NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, sympathomimetics, antacids (reduce bioavailability by 45 %). Potassium-sparing diuretics, the cyclosporines, potassium-containinging pharmaceuticals and additives, substitutes of salt, milk with the low maintenance of salts enlarge risk of development of a hyperkalemia. The drugs oppressing function of an osteal brain (immunodepressants, cytostatics and-or Allopyrinolum), rise risk of development of a neutropenia and-or an agranulocytosis with a lethal outcome. Strengthens oppressing action of alcohol on the CNS. The probenecid retards deducing Captoprilum with urine.

Capoten Overdosage: Signs: an acute arterial hypotension, infringement of a cerebral circulation, a myocardial infarction, a thromboembolism, a Quincke's disease. Treatment: decrease of a dose or a complete cancellation of a drug; a gastric lavage, translation of the patient in a horizontal position, carrying out of actions on augmentation the BLOOD VOLUME (introduction of an isoosmotic solution of a sodium of Sodium chloridum, decantation of other blood-substituting liquids), symptomatic therapy: Epinephrinum (subcutaneous or intravenously), antihistaminics, Hidrocortizonum (intravenously). Carrying out of a haemodialysis, if necessary use of the synthetic driver of a rhythm.

Capoten Way of application and dose: Inside, 1 h prior to meal. At an arterial hypertension: an initial dose - 12,5 mg 2 times day, if necessary a single dose enlarge up to 50 mg 3 times day with intervals 2-4 weeks; a maintenance dose of 25 mg 2-3 times day; a maximal daily dose - 150 mg. At a renovascular and renal hypertension: an initial dose - 6,25 mg 3 times the day, bolstering - 25 mg 3 times day. At a chronic heart failure, in the postmyocardial infarction period: an initial dose - on 6,25 mg 3 times day with the subsequent rising (everyone 2-3 weeks) up to a maintenance dose of 25 mg 2-3 times day or up to 50 mg 3 times day (in the postmyocardial infarction period). A maximal daily dose - 150 mg. At infringement of function of kidneys: the initial dose of 6,25 mg 2-3 times day with the subsequent augmentation, a maximal dose depends on a clearance of a creatinine: at a clearance 35-130 ml /1,73 of m2 - 150 mg, 20-35 ml /1,73 of m2 - 75 mg, less than 20 ml /1,73 of m2 - 37,5 mg.

Capoten Precautionary measures: Treatment is carried out under the regular medical control. Prior to the beginning of treatment (for 1 weeks) previous hypotensive therapy should be cancelled. At patients with malignant current of a hypertension each 24 h I fade in a dose up to achievement of maximal effect under the control the HELL. During therapy monitoring the HELL, patterns of a peripheric blood (before the beginning of treatment, in the first 3-6 month of treatment and with periodic intervals further till 1 year, it is especial at patients with the raised risk of a neutropenia), a level of protein, a potassium in plasma, a urea nitrogen, a creatinine is necessary, for function of kidneys, masses of a body, a diet. At development of a hyponatremia, a dehydration correction of a regimen of dosing (decrease of a dose) is necessary. or urticarial (less often) the eruption arises during the first 4 weeks of treatment, disappears at decrease of doses, cancellations of a drug and introduction of antihistaminics. The dose-dependent neutropenia develops during 3 month after the beginning of therapy (maximal decrease of number of leucocytes is observed within 10-30 days and it is conserved about 2 weeks after a cancellation of a drug). Tussis (it is observed at women more often) occurs within the first week more often (from 24 o'clock up to several the month) therapies, is conserved during treatment and stopped in some days after the termination of therapy. Infringement of taste and dropping of mass of a body are convertible and reduced through 2-3 month of therapy. Care is necessary at carrying out of operative measures (including stomatologic), is especial at use of the general Anesthetics Chloroformium rendering hypotensive action. At development of a cholestatic icterus and progressing of a fulminant necrosis of a liver treatment should be stopped. It is necessary to avoid carrying out of a haemodialysis through high capacity membranes from (for example, N69), hemofiltrations or the -PHERESIS (development of an anaphylaxis or anaphylactoid reactions is possible). Hyposensitization therapy can rise risk of development of anaphylactic reactions. It is recommended to exclude the use of alcoholic drinks during treatment. With care to apply in an operating time to drivers of vehicles and people which trade is connected to the raised concentration of attention.

Capoten Special indicatings: In case of the miss of a dose the subsequent dose do not double. At carrying out of the paste for an acetonuria the positive take is possible.

Trading names of drugs with working substance Captopril:
(Angiopril-25) Captoprilum (Captopril) Captoprilum - (Captopril-STI) (Aceten) Captoprilum (Captopril HEXAL) Captoprilum - (Captopril-Teva) Captoprilum - (Captopril-AKOS) Captoprilum - (Captopril-Ferein) -Captoprilum (Vero-Captopril) Captoprilum - (Captopril-Akri) Captoprilum - (Captopril FPO) (Capocardum) the Captoprilum - biosynthesis (Captopril-Biosynthes) Captoprilum - (Captopril-Egis) (Capoten) Captoprilum - (Captopril-KMP) (Rilcapton) (Capopharm) Captoprilum - (Captopril-MIK) (Capto) Captoprilum (Captopril-N.S).