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Medical Information:
Entacapone (in-TACK-a-pohn)is used in combination with levodopa/carbidopa to treat Parkinson's disease, sometimes referred to as shaking palsy. Some patients experience signs and symptoms of end-of-dose Comtan is manufactured by Novartis. Comtan is a catechol-o-methyltransferase (COMT) inhibitor used along with levodopa/carbidopa to treat Parkinson's disease.
Digoxin tablets and injection both contain the active ingredient digoxin, which is a type of medicine called a cardiac glycoside.
Digoxin is a form of digitalis, a drug that is extracted from the leaves of the foxglove plant. It is used to treat arrhythmias, atrial fibrillation and heart failure. Digoxin is also available without a brand name, ie as the generic medicine.
Digoxin works directly on the heart muscle. It slows down the rate at which the heart beats, and also increases the force with which the heart muscle contracts with every heartbeat. This makes each heartbeat more efficient at pumping blood around the body.
Digoxin is used to treat certain abnormal heart rhythms caused by abnormal contractions in the upper part of the heart, in particular a condition called atrial fibrillation (AF). In AF, the upper two chambers of the heart, called the atria, contract very rapidly, and the lower two chambers of the heart, called the ventricles, respond by beating rapidly and irregularly. An irregular heartbeat is not very efficient at pumping blood around the body. By slowing the heart rate and making each beat more forceful, digoxin makes the heart pump more efficiently in this condition.
Digoxin is also used to treat heart failure, a condition where the heart's ability to pump blood around the body is diminished. By improving the efficiency of each heartbeat, digoxin allows the heart to continue to effectively pump blood and oxygen around the body.P>The blood level of digoxin that is needed for it to be effective is quite close to the blood level that can cause unwanted effects. This is true of a few medicines, and is described as a narrow therapeutic index. Treatment with the medicine is still safe, but your doctor will monitor your digoxin treatment closely, and may take blood tests to check the level of digoxin in your blood. You should tell your doctor if you experience any side effects during treatment, particularly nausea and vomiting, loss of appetite, visual disturbances, heart palpitations or confusion, as these may indicate your blood level of digoxin is too high and that your dose needs reducing.
What is it used for?
Heart failure.Abnormal heart rhythms caused by abnormal contractions in the upper part of the heart (supraventricular arrhythmias).Irregular heartbeat caused by very rapid contraction of the top two chambers of the heart (atrial fibrillation).
How to use Digoxin Oral -Take this medication by mouth with or without food, usually once daily or as directed by your doctor. Certain foods and medications decrease the absorption of digoxin. Therefore, take digoxin at least 2 hours before or after eating food products high in fiber (such as bran). If you are taking cholestyramine, colestipol, or psyllium, wait at least 2 hours after your digoxin dose before taking any of these products. If you are taking antacids, kaolin-pectin, milk of magnesia, metoclopramide, sulfasalazine, or aminosalicylic acid, take as far apart as possible from your digoxin dose.
Dosage is based on your medical condition, age, body weight, and response to therapy.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped.
Inform your doctor if your condition persists or worsens.
Before using -Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking azathioprine. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking alkylating agents (such as cyclophosphamide, chlorambucil, or melphalan), allopurinol, angiotensin converting enzyme inhibitors (such as enalapril or lisinopril), anticoagulants (such as warfarin), aminosalicylates (such as olsalazine, mesalazine, or sulfasalazine), disease modifying antirheumatic drugs (such as methotrexate or adalimumab), doxorubicin, hydantoins (such as phenytoin), or trimethoprim/sulfamethoxazole. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including infection, or a history frequent or prolonged infections; recent chicken pox infection; blood problems (such as anemia, unusual bruising or bleeding, low white blood cell counts, or low platelet counts); bone marrow problems; certain enzyme deficiencies (such as thiopurine methyltransferase or xanthine oxidase deficiency); gout; liver or kidney problems; recent blood transfusions; recent vaccinations; allergies; pregnancy; or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have previously taken this medicine or thioguanine and your cancer did not respond. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Directions -Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. Check with your doctor or nurse for instructions. ASK YOUR DOCTOR if you should follow any special guidelines for handling this medicine. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly-closed container, away from heat, moisture and light. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
Cautions -DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. Laboratory and/or medical tests, including liver function tests, complete blood cell counts, and TPMT enzyme activity may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are taking this medicine. CHECK WITH YOUR DOCTOR BEFORE HAVING IMMUNIZATIONS (VACCINATIONS) while you are taking this medicine. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. THIS MEDICINE MAY LOWER YOUR RESISTANCE TO INFECTION. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. THIS MEDICINE MAY INCREASE YOUR RISK OF developing a tumor or other cancer. Contact your doctor right away if you notice any unusual growths or lumps. Discuss any questions or concerns with your doctor. AN ENZYME CALLED TPMT helps to break this medicine down in the body. Infrequently, some patients may have decreased TPMT enzyme activity. This may increase the risk of developing serious side effects (such as bone marrow problems). Patients with decreased TPMT activity enzyme may need a lower dose of this medicine. Discuss any questions or concerns with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: THIS MEDICINE HAS BEEN SHOWN TO CAUSE HARM to the human fetus. Avoid becoming pregnant while you are taking this medicine. IF YOU THINK YOU MAY BE PREGNANT, contact your immediately. IT IS UNKNOWN IF THIS DRUG IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.