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Calcigard Retard - the description, contraindications, application
The latin name: Calcigard Retard
Calcigard Pharmacological groups: Blockers of calcium canals
Calcigard Working substance: Nifedipinum (Nifedipine)
Calcigard Application: the Arterial hypertension, including a hypertonic crisis, prophylaxis of attacks of a stenocardia (including stenocardias ), a hypertrophic cardiomyopathy (obstructive, etc.), a Raynaud's disease, a pulmonary hypertension, a set of symptoms.
Calcigard Contraindications: Hypersensitivity, the acute period of a myocardial infarction (the first 8 days), a cardiogenic shock, a serious aortal stenosis, a heart failure in a stage of the decompensation, the expressed arterial hypotension, a tachycardia, pregnancy, a feeding a breast.
Calcigard Restrictions to application: It is necessary to refrain from application of a drug in pediatric practice as safety and efficiency of his application for children are not determined.
Calcigard Application at pregnancy and a feeding a breast: It counterindicative. For the period of treatment it is necessary to stop thoracal feeding.
Calcigard Side effects: From the side of cardiovascular system and a blood (a hemopoiesis, a hemostasis: frequently (in the beginning of treatment) - a hyperemia of the person with sensation of fever, palpitation, a tachycardia; rarely - a hypotension (down to a syncope), a pain similar stenopeic, it is very rare - an anemia, a leukopenia, a thrombocytopenia, a Werlhof's disease. From the side of nervous system and sense organs: in the beginning of treatment - the giddiness, a headache, is rare - an obnubilation, very rare - change of a vision, infringement of sensitivity in arms and legs. From the side of bodies of the GASTROINTESTINAL TRACT: frequently - a constipation, it is rare - a nausea, a diarrhea, it is very rare - a hyperplasia a gum (at long treatment), rising of activity of hepatic transaminases. From the side of respiratory system: very rarely - a spastic stricture of bronchuses. From the side of a locomotorium: very rarely - a myalgia, a tremor. Allergic reactions: an itch, a urticaria, exanthemas, it is rare - an exfoliative dermatitis. Other: Frequently (in the beginning of treatment) - a tumescence and a reddening of arms and legs, it is very rare - a photodermatitis, a hyperglycemia, a gynecomastia (at patients of advanced age), sensation of a burning sensation in a place of an injection (at intravenously introduction).
Calcigard Interaction: Sodium nitritums, beta - adrenoblockers, diuretics, tricyclic antidepressants, Fentanylum, alcohol - strengthen hypotensive effect. Rises activity of Theophyllinum, reduces a renal clearance of digoxin. Strengthens side effects of Vincristinum (reduces deducing). Rises bioavailability of cephalosporins . Cimetidinum and rise a level in plasma. Diltiazems retards a metabolism (decrease of a dose of Nifedipinum is required). It is incompatible with Rifampicinum (accelerates a biotransformation and does not allow to frame efficiency concentrations). Juice of a grapefruit (plenty) enlarges bioavailability.
Calcigard Overdosage: Signs: a sharp bradycardia, a bradyarrhythmia, an arterial hypotension, in serious cases - a collapse, retardation of conduction. At reception of the big number of -tablets attributes of an intoxication are displaid not earlier than in 3-4 h and hyperglycemias, a metabolic acidosis, a hypoxia can follow-up be expressed in a loss of consciousness down to a coma, a cardiogenic shock, cramps. Treatment: a gastric lavage, reception of absorbent coal, introduction of Norepinephrinum, calcium of Sodium chloridum or calcium of a gluconate in a solution of Atropinum (intravenously). The haemodialysis is noneffective.
Calcigard Way of application and dose: Inside, sublingually, intravenously. Inside, during time or after meal, as tablets, sheaths, a dragee, the adult - on 10 mg 3-4 times day. In special cases (an alternative stenocardia, a serious arterial hypertension) - the augmentation of a dose up to 20 mg of 4-6 times day for short time is possible. A maximal daily dose - 120 mg. At an arterial hypertension - on 10 mg 3 times day (if necessary a dose enlarge within 7-14 days up to 20-30 mg by reception. For a cupping of a hypertonic crisis and an attack of a stenocardia of 10-20 mg sublingually or inside it is single-pass, if necessary - through 10 mines repeatedly as sheaths and tablets of prolonged action (the sheath is recommended to be got to the core or pierced preliminarily) - on 20-40 mg 2 times day (at stenocardia - up to 120 milligram/day); as tablets - 40-80 mg of 1 times day (the tab. do not chew). Intravenously (a cupping of a hypertonic crisis) - 5 mg within 4-8 h (0,0104-0,0208 mg / mines), or 6,3-12,5 mls / h). A maximal dose - 15-30 milligram/day (can be utilised no more than 3 days).
Calcigard Precautionary measures: Elderly patients are recommended to decrease a daily dose (dropping of a metabolism). With care to apply in an operating time to drivers of vehicles and people which trade is connected to the raised concentration of attention. To cancel a drug follows gradually (probably development of a withdrawal).
Calcigard Special indicatings: patients with a stable stenocardia in the beginning of treatment can have paradoxical intensifying of anginal pains, at the expressed coronarosclerosis and a unstable stenocardia - aggravation of an ischemia of a myocardium. It is not recommended to use drugs of short action for long treatment of a stenocardia or an arterial hypertension since development of unpredictable changes the HELL and a reflex stenocardia is possible.
Trading names of drugs with working substance Nifedipine:
Adalatum (Adalat) (Cordipin XL) Nifedipinum - (Nifedipin-Farkos) Adalatum (Adalat SL) (Cordipin retard) Nifedipinum - (Nifedipin-FPO) -Nifedipinum (Vero-Nifedipine) Corinfarum (Corinfar) (Nifecard XL) -? (Depin-E) Corinfarum (Corinfar retard) Nifelatum (Nifelat) (Calcigard Retard) (Nicardia) Adalatum (Osmo-Adalat) - (Carin-Fer) (Nicardia CD retard) (Fenamon) (Cordafen) Nifedipinum (Nifedipin) Phenihydinum (Phenyhydinum) (Cordaflex) Nifedipinum - (Nifedipin-MIK) Phenihydinum of a tablet of 0,01 g (Tabulettae Phenihidini 0,01 g) (Cordipin) Nifedipinum - (Nifedipin-ratiopharm)