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Drugs group	Short description
Generic COLOSPA (Mebeverine)	Colospa (Mebeverine) acts directly on the smooth muscle in the gut causing it to relax. It also prevents nerve signals getting through to the muscle in the intestines. This also causes the muscle to relax, preventing painful muscle spasm. Little or no antispasmodic effect was seen on the uterus and the bronchial muscles. Gastric emptying time and intestinal propulsion were affected much less than by papaverine. No significant inhibition of normal peristalsis has been observed.
COLOSPA (Colofac, Generic Mebeverine)	Colospa is manufactured by Duphar, India.COLOSPA is used to relieve thesymptoms of irritable bowelsyndrome, which include, abdominalpain and cramps, bowel spasm,diarrhoea and flatulence.COLOSPA belongs to a group ofmedicines known as antispasmodicagents. COLOSPA is also known as mebeverine hydrochloride.COLOSPA works by relaxing themuscles in the gut, thereby relievingthe symptoms of irritable bowelsyndrome
Mebeverine, COLOSPA
COLOSPA ( Colofac, Generic Mebeverine )	Category : Antispasmodic; smooth muscle relaxant. Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings Relief of abdominal pain, cramps, bloating and wind, diarrhoea or constipation associated with irritable bowel syndrome.

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