Betamethasone - the description, contraindications, application

The latin name: Betamethasone

Pharmacological groups: Glucocorticoids

Betamethasone Working substance: Betamethasone

Betamethasone Application: the Congenital hypoplasia of paranephroses, adrenal failure (it is routine in a combination to mineralocorticoids); a shock (anaphylactic, endotoxic, hemodynamic); a thyroiditis (acute, chronic), a thyrocardiac crisis, a hypercalcemia owing to malignant neoplasms; a pseudorheumatism in a phase of an exacerbation, an acute rheumatic carditis, a systemic lupus erythematosus, a scleroderma, etc. general diseases of a connecting tissue, inflammatory defeats of joints and soft tissues, including periarthric (an arthritis traumatic, acute gouty, etc. a genesis, an osteoarthritis, an osteochondritis, a bursitis, a fibrositis, a tendinitis, a tendovaginitis, Bekhterev illness, a myositis); prophylaxis of reaction of a graft rejection; a nephrotic set of symptoms; serious allergic, including anaphylactoid reactions (caused by the pharmaceuticals, connected to a hemotransfusion, allergic rhinites, a Quincke's edema, a serum disease, etc.); a bronchial asthma (including the asthmatic status), a sarcoidosis, a berylliosis, a Loffler's syndrome, an aspiration pneumonitis; a wet brain (traumatic, postoperative, metastatic, postinsult); a neurodermite, a dermatitis (idle time, exfoliative, solar, seborrheal, radiative, violent herpetiform, contact, atopic, the bottom extremities at a circulatory unefficiency, etc.), An eczema (a nursery, atopic, nummularis), a psoriasis, an intertrigo, a nesting alopecia, colloidal seams, nodulose prurigo , an itch (senile, anogenital), a polymorphic exudative erythema, an erythrosis, a pemphigus, a fungoides mycosis, etc. dermal diseases; a relapsing aphthous stomatitis; a nonspecific ulcerative colitis, illness of the Crown; an anemia (autoimmune hemocatheretic, congenital hypoplastic), an idiopathic and secondary thrombocytopenia at adults, an acute leukemia at children, lymphomas , a lymphoid leukosis (chronic); an allergic conjunctivitis and a helcoma, a keratitis, an iridocyclitis, an iritis, a chorioretinitis, a diffuse choroiditis, a retrobulbar neuritis, prophylaxis of a -set of symptoms at newborns, a croup at a diphtheria, a tubercular meningitis, a tetanus (in a combination to antimicrobic agents); a cancer of lactic Ferri lactas, a prostate.

Betamethasone Contraindications: Hypersensitivity, systemic mycosises, the INFECTION, active forms of a tuberculosis, a chicken pox, simple herpes, including an eye, oral cavities, etc. virus diseases, the period of bacterination, round ulcers of the GASTROINTESTINAL TRACT, a peptic ulcer of a stomach and a duodenal intestine (in a phase of an exacerbation), a diverticulitis, an esophagitis, a gastritis, fresh intestinal anastomoses, a stagnant heart failure, a thrombophlebitis, an arterial hypertension, a diabetes, a Cushing's syndrome, an osteoporosis, a myasthenia, a hypoalbuminemia, serious infringements of function of a liver and kidneys, psychosises, an open angle glaucoma, pregnancy (including a preeclampsia, an eclampsia), a feeding a breast (it is especial at high doses of a drug); intra-articular, in the center of defeat: the unstable joints, a previous arthroplasty, the periarthric infection, the infected centers of defeat, infringement of coagulation of a blood; outwardly: Acnes (pink, ordinary), initial virus, fungic, bacterial, including a tuberculosis, infections of a skin and a pilar part of a head; at children till 1 year an eruption (on a background of an intertrigo), a dermatitis and dermatoses.

Betamethasone Side effects: the Hypokalemia, muscle delicacy, a myopathy, an osteoporosis, spontaneous fractures, an arterial hypertension, a myocardial dystrophy, arrhythmias, a clottage and a thromboembolism, -cankers of the GASTROINTESTINAL TRACT, steroid Diabetum, downstroke of immunity and activation of infectious diseases, a suppression hypothalamic-pituitary adrenal system, occurrence of a hirsutism and acnes, infringement of a regularity of a menses, an Itsenko-Cushing syndrome, increase of weight, infringement of dream, euphoria, exaltation or depression, alarm, a psychosis, a glaucoma, a cataract, a steroid exophthalmia, a withdrawal (at the sharp termination of long therapy); rarely - a delay of a sodium and waters (edemas); locally - an itch, a hyperemia, a burning sensation, dryness, infringement of a pigmentation, a dermatitis (perioral, allergic), a maceration and an atrophy of a skin, a heat rash, the secondary infections of a skin and mucosas.

Betamethasone Interaction: Therapeutic, toxic effects reduce inductors of enzymes of a liver, strengthen - estrogens and peroral contraceptives, probability of arrhythmias and hypokalemias - glycosides Digitalis, diuretics (causing deficiency of a potassium), Amphotericinum B, inhibitors of a carbonic anhydrase, risk of -erosive defeats or bleedings in the GASTROINTESTINAL TRACT - alcohol and the NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; probability of infections and developments of lymphomas, etc. diseases - immunodepressants, an opportunity of occurrence of a fluid lungs at pregnant - Ritodrinum. Weakens hypoglycemic activity of antidiabetic agents and an insulin, atrial natriuretic and diuretic - diuretic, activity of vaccines (because of downstroke of development of antibodies); - derivants of tonka-bean camphor and an indandione, Heparinum, Streptokinasa and a urokinase. Enlarges a hepatotoxic of Paracetamolum. Reduces concentration in a blood of Salicylases.

Betamethasone Overdosage: Signs: a nausea, a vomiting, frustration of dream, euphoria, exaltation, depression. At long application in high doses - an osteoporosis, a delay of a liquid in an organism, rising the HELL, etc. attributes of a hypercorticoidism, including an Itsenko-Cushing syndrome, the secondary adrenal failure. Treatment: on a background of a gradual cancellation of a drug maintenance of the vital functions, correction of electrolytic balance, antacids, phenothiazines, drugs of a lithium; at an Itsenko-Cushing syndrome.

Betamethasone Way of application and dose: Inside, parenteral, locally. Inside, during meal; to adults and teenagers - it is single-pass, preferable in the morning (a small dose) or in 2-3 receptions (the big dose) - from 0,25-0,6 mg up to 7,2-8 milligram/day; after long therapy the dose is reduced gradually by 0,25-0,5 mg with each 2-3 day. At rheumatic diseases - the initial dose of 1-2,5 mg bolstering - 0,5-1,5 milligram/day, a bronchial asthma - 3,5 mg, then - 0,25-0,5 milligram/day, the asthmatic status - 3,5-4,5 milligram/day, pollinoses - 1,5-2,5 milligram/day, an adrenogenital set of symptoms - 1-1,5 milligram/day; a maintenance dose select individually. To children - 0,0625-0,2 mg / kg or 1,975-7,5 mg / m2 of area of surface of a body day. Parenteral: to adults and teenagers - intravenously it is sluggish or it is trickling in the beginning on 4-8 milligram/day (if necessary - up to 9-20 mg), then in a maintenance dose - 2-4 mg; intramuscularly - 4-6 mg (up to 9 mg) in day. At a wet brain - intravenously 2-4 mg, single-passly, a coma - 2-4 mg 4 times day. At reaction of a casting-off of a renal allotransplant - it is intravenously trickling, 60 mg within 24 h. To children - intramuscularly, 0,021-0,125 mg / kg day or 0,625-3,75 mg / m2 each 12-24 h. Intra-articular and para-articular (adult) - in the big joints - 2-4 mg (up to 9 mg), small - 0,8-2 mg are not more often than 1 time in 3 weeks. In area of defeat, in a synovial bag - 2-3 mg, tendinous vaginas - 0,4-1 mg; soft tissues - 2-6 mg; ganglions - 1-2 mg; a callositas - 0,4-1 mg; intracutaneous in the center of defeat - (it is (no more) 0,1 mg / sm2, no more than 2 mg in a week dose; in case of need admix with local anesthetics (1 % a solution of Lidocainum, Procainum). Subconjunctival - in a center dose of 2 mg. Outwardly - render a shallow layer (Unguentum, a cream) or some drops (lotion) on the struck sites of a skin from 2 up to 6 times day before clinical improvement, then - no more than 1-2 times day (use of an occlusive dressing is possible); course of treatment at children and sick persons with defeat - no more than 5 days.

Betamethasone Precautionary measures: With care use at a diabetes, simple herpes of a cornea, a systemic lupus erythematosus (the risk of an aseptic necrosis increases), an osteoporosis, at patients with risk of a clottage (appoint on a background of anticoagulants), at elderly (the risk of an arterial hypertension, an osteoporosis is raised, it is especial at women in the postclimacteric period), at children, only on a background of corresponding antibacterial therapy - at abscesses, purulent infections, a tuberculosis. It is necessary to take into account intensifying of action at a hypothyroidism, a cirrhosis of a liver, probability of development (it is especial at long application) relative adrenal failure (within several months after a cancellation of a drug). At long treatment it is necessary to observe carefully of dynamics of body height and development at children, periodically to carry out ophthalmologic inspection (for revealing a glaucoma, a cataract, etc.), On a regular basis to supervise function -- systems, the maintenance of a glucose in a blood and urine (it is especial at patients with a diabetes), electrolytes in Serum, an occult blood in excrements. During therapy an immunization, the use of alcoholic drinks avoid.

Betamethasone Special indicatings: In order to prevent an overdosage calculation of a dose is preferable, proceeding from square meter of area of surface.

Trading names of drugs with working substance Betamethasone:
(Akriderm) a sodium Natrii phosphas (Betamethasone sodium phosphate) (Diprospan) (Beloderm) (Betamethasoni valeras) (Flosteron) (Betasone) Dipropionas (Betamethasone dipropionate) -? (Celestoderm-V) (Betacortal) (Betnovate) Celestonum (Celestone)