ACOMPLIA ( Generic Rimonabant )
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Appetite suppressant , Anti obesity drug. Acomplia is used complementary to diet and exercise to treat .obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the bloodA single pill has been found to stop both food and cigarette cravings enough to help people quit smoking and lose weight, and could also help curb other unhealthy urges. In one study the medicine helped people who were overweight drop an average of 20 pounds and in another doubled the chances that smokers would quit. Acomplia contains the active ingredient Rimonabant. It is a selective CB1 Endocannabinoid Receptor Antagonist.Acomplia works by blocking receptors of a substance called cannabinoid 1, which stimulates hunger and other cravings in the brain and is also present in fat tissue. Sanofi argues that Acomplia can also prevent the risk ofCardiovascular disease.Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug.ACOMPLIA
Acomplia contains Rimonabant, the long awaited breakthrough drug by Sanofi for the treatment of obesity and smoking cessation. Advertised in America as Zimulti.Acomplia represents one of the latest and indeed a most novel method for controlling body weight. It operates by being a cannabinoid receptor antagonist. This means that it prevents the normal action of endogenous cannabinoid in the brain from stimulating the so-called CB1 receptors. It would appear that these receptors stimulate appetite and therefore when they are subdued so is the need to eat. With specific regard to weight loss, the human trials have shown an average weight loss of 10% of bodyweight, most importantly that weight has remained off even up to 2-years later. Also importantly, it would appear that the majority of weight is actually lost from the difficult to lose area around the waist. The average figures from the trials show a loss of fat of 20 lbs (9 Kg) and 3 inches (8 cm) diameter taken off the waist. Acomplia has also been shown to improve HDL (good cholesterol), cardiovascular factors such as cholesterol ratios and triglyceride levels, showing benefit for diabetes and heart conditions by subduing receptors which stimulate appetite. Acomplia Effects - Despite having strengths like weight reduction and increasing good cholesterol numbers the FDA has not acted regarding the approval of the drug as yet. Like all drugs acomplia too is not free from the health risks and side effects. It has certain disadvantages as well, the most dreadful of which is that Acomplia showed about 2.7 fold higher brain disorder rate in a clinical trial among the patients treated with Acomplia v/s the patients with placebo. In a presentation at the Annual Metabolic Diseases Drug Discovery World Summit, Sanofi-Aventis threw light on the latest industry and academic advancements by the leading concerns engaged in the study of obesity and diabetes. At this world summit the company addressed the role of Acomplia in clinical development in disorders related to obesity. |
